ISL2 Antikörper (AA 201-300) (Biotin)
Kurzübersicht für ISL2 Antikörper (AA 201-300) (Biotin) (ABIN1390579)
Target
Alle ISL2 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 201-300
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Homologie
- Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit
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Aufreinigung
- Purified by Protein A.
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Immunogen
- KLH conjugated synthetic peptide derived from human Islet 2
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Isotyp
- IgG
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Applikationshinweise
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 μg/μL
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Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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Konservierungsmittel
- ProClin
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Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Store at -20°C for 12 months.
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Haltbarkeit
- 12 months
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- ISL2 (ISL LIM Homeobox 2 (ISL2))
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Andere Bezeichnung
- Islet 2
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Hintergrund
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Synonyms: Insulin gene enhancer protein ISL 2, Insulin gene enhancer protein ISL-2, Insulin gene enhancer protein ISL2, ISL 2, ISL 2 transcription factor, ISL 2 transcription factor LIM/homeodomain, ISL2, ISL2 transcription factor, ISL2 transcription factor LIM/homeodomain, ISL2_HUMAN, Islet-2, Islet2, FLJ10160.
Background: Islet-2 (insulin gene enhancer protein ISL-2) is a 359 amino acid protein encoded by the human gene ISL2. Islet-2 is a nuclear protein that contains two N-terminal LIM domains, followed by a homeodomain and a serine/ glutamine/threonine-rich C-terminus. Islet-2 is a transcriptional factor that defines subclasses of motor neurons that segregate into columns in the spinal cord and select distinct axon pathways. Islet-1 and Islet-2 are initially ex-pressed by all postmitotic spinal motor neurons prior to diversification of somatic and visceral neuronal fates. Somatic, but not visceral, motor neurons maintain Islet-2 expression at later embryonic stages. An early phase of Islet-2 expression by prospective visceral motor neurons of the sympathetic preganglionic motor column is critical for the emergence of complete visceral motor neuron character. Mutations that reduce or eliminate both Islet-1 and Islet-2 activity will result in pronounced defects in visceral motor neuron generation and eroded somatic motor neuron character.
Target
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