Endothelin 2 Antikörper (AA 49-59) (AbBy Fluor® 647)

Produktnummer ABIN1390332

Dieses Anti-Endothelin 2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Endothelin 2 in IF (cc) und IF (p). Geeignet für Cat.

Kurzübersicht für Endothelin 2 Antikörper (AA 49-59) (AbBy Fluor® 647) (ABIN1390332)

Target: Endothelin 2 (EDN2)

Reaktivität: Cat

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Endothelin 2 Antikörper ist konjugiert mit AbBy Fluor® 647

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-Endothelin 2 Antikörper (AbBy Fluor® 647)

Bindungsspezifität: AA 49-59

Kreuzreaktivität: Cat

Homologie: Human,Mouse,Rat,Dog,Cow,Cat,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Endolin 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Endothelin 2

Target: Endothelin 2 (EDN2)

Andere Bezeichnung: ET-2/Endothelin 2

Hintergrund:

Synonyms: EDN2, EDN2_HUMAN, Endothelin 2, Endothelin-2, ET 2, ET-2, ET2, PPET2, Preproendothelin 2, Preproendothelin-2.

Background: The endothelin (ET) family of proteins, which includes ET-1 (endothelin-1), ET-2 (endothelin-2) and ET-3 (endothelin-3), are vasoactive peptides that are involved in various functions throughout the body. Endothelins can affect the central nervous system and neuronal excitability, and they elicit potent vasoconstrictor action. While ET-1 is a potent, 21-amino acid vasoconstrictor peptide, ET-2 has the most potent vasoconstrictor activity. ET-3 functions as a ligand for endothelin receptor type B (ETBR) and, through this interaction, mediates the maturation of enteric neurons and melanocytes. Although ET-3 is expressed as a 238 amino acid peptide, it is post-translationally modified to produce a short active isoform and a long inactive isoform. Defects in the gene encoding ET-3 are the cause of a variety of disorders, including Hirschsprung disease type 1 (HSCR1), congenital central hypoventilation syndrome (CCHS) and Waardenburg syndrome type IV (WS4).

Pathways: Hormone Activity, Negative Regulation of Hormone Secretion, Regulation of Systemic Arterial Blood Pressure by Hormones