LEFTY1 Antikörper (AA 51-150) (Biotin)

Produktnummer ABIN1390081

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch LEFTY1 in ELISA, IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für LEFTY1 Antikörper (AA 51-150) (Biotin) (ABIN1390081)

Target: LEFTY1 (Left-Right Determination Factor 1 (LEFTY1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LEFTY1 Antikörper ist konjugiert mit Biotin

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-LEFTY1 Antikörper (Biotin)

Bindungsspezifität: AA 51-150

Homologie: Human,Mouse,Rat

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Lefty

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu LEFTY1

Target: LEFTY1 (Left-Right Determination Factor 1 (LEFTY1))

Andere Bezeichnung: Lefty

Hintergrund:

Synonyms: Protein lefty-1, AI450052, Ebaf, Left right determination factor 1, left right determination factor, Left right determination factor B, left-right determination factor, LEFT-RIGHT DETERMINATION FACTOR 1, LEFTY1, left-right determination, factor B, LEFT-RIGHT DETERMINATION, FACTOR B, LEFTY B, LEFTB, LEFTY 1, Lefty, lefty-1, LEFTY1, LEFTY1, MOUSE, HOMOLOG OF antibody, LEFTYB, Protein lefty-B, RGD1561867, Stimulated by retinoic acid gene 3 protein, STRA3, TGF beta 4, TGF-beta-4, Tgfb4, Transforming growth factor beta 4, Transforming growth factor beta-4.

Background: During vertebrate embryogenesis, a left right axis is established. Secreted growth factors of the TGF beta family, including gene products derived from nodal, lefty 1 and lefty 2, play crucial roles in establishing left right asymmetries. TGF beta (Transforming growth factor beta) is a pleiotropic cytokine that regulates growth and differentiation of diverse types of cells. TGF beta actions are directed by ligand induced activation of TGF beta receptors. Complexes formed move into the nucleus, where they act as components of a transcriptional complex. Lefty, a novel member of the TGF beta superfamily, inhibits TGF beta signaling. Lefty acts to inhibit phosphorylation of Smad2 following activation of the TGF beta receptor. Lefty also inhibits events downstream from R Smad phosphorylation. Lefty provides a repressed state of TGF beta responsive genes. The Lefty family is comprised of Lefty 1 and Lefty 2 in mouse, and Lefty A and Lefty B in humans. Members of the TGF beta superfamily require processing for their activation. Cleavage is therefore an essential step for Lefty activation. Lefty is synthesized as a large inactive precursor (41 Kda) that must be endoproteolytically processed to release the bioactive polypeptide (28 kDa and 34 kDa forms). The 28 kDa form induces MAPK activity.

Gen-ID: 10637