MYRIP Antikörper (AA 101-200)

Produktnummer ABIN1387849

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MYRIP in ELISA, WB, IHC (p), ICC, IF (cc), IF (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für MYRIP Antikörper (AA 101-200) (ABIN1387849)

Target: MYRIP (Myosin VIIA and Rab Interacting Protein (MYRIP))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MYRIP Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-MYRIP Antikörper

Bindungsspezifität: AA 101-200

Homologie: Human,Mouse,Rat,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MYRIP/SLAC2-C

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu MYRIP

Target: MYRIP (Myosin VIIA and Rab Interacting Protein (MYRIP))

Andere Bezeichnung: MYRIP/SLAC2-C

Hintergrund:

Synonyms: exophilin 8, exophilin, Exophilin-8, Exophilin8, Myosin VIIA and Rab interacting protein, Myosin-VIIa- and Rab-interacting protein, MyRIP, MYRIP_HUMAN, rab effector MYRIP, SLAC 2C, SLAC2 C, SLAC2-C, SLAC2C, Slp homolog lacking C2 domains c, Slp homologue lacking C2 domains, Slp homologue lacking C2 domains c antibody Synaptotagmin like protein homologue lacking C2 domains c, synaptotagmin-like protein homologue lacking C2 domains-c.

Background: Slac2-c is a Rab effector protein that is expressed in a variety of tissues including brain, heart, skin and liver. Found in the basal microvilli of retinal pigment cells and in pre- and post-synaptic areas in photoreceptor cells , Slac2-c is involved in melanosome transport and functions to link Rab 27a with the actin-based motor proteins Myosin Va and Myosin VIIa. Once linked, the Myosins are able to transport Rab 27a to retinal melanosomes, thereby linking the actin cytoskeleton with the melanosome membrane. Slac2-c contains one FYVE-type zinc finger and one Rab-binding domain and is able to bind actin-like proteins through its conserved C-terminal region. Additionally, Slac2-c is thought to regulate the final steps of insulin exocytosis by mediating the interaction of secretory granules with the cortical actin cytoskeleton.

Pathways: Positive Regulation of Peptide Hormone Secretion