RCAN3 Antikörper (AA 151-241)

Produktnummer ABIN1387777

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RCAN3 in WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) und ICC. Er zeigt eine Reaktivität gegenüber Maus und Ratte.

Kurzübersicht für RCAN3 Antikörper (AA 151-241) (ABIN1387777)

Target: RCAN3 (RCAN Family Member 3 (RCAN3))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RCAN3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Produktdetails anti-RCAN3 Antikörper

Bindungsspezifität: AA 151-241

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Cow,Sheep,Pig,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Calcipressin 3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu RCAN3

Target: RCAN3 (RCAN Family Member 3 (RCAN3))

Andere Bezeichnung: Calcipressin 3

Hintergrund:

Synonyms: Calcipressin-3, Down syndrome candidate region 1 like 2, regulator of calcineurin 3, Down syndrome candidate region 1 like protein 2, Down syndrome candidate region 1-like protein 2, Down syndrome critical region gene 1 like 2, DSCR1L2, hRCN3, MCIP3, Myocyte enriched calcineurin interacting protein 3, Myocyte-enriched calcineurin-interacting protein 3, RCAN family member 3, RCAN3, RCAN3_HUMAN, RCN3, Regulator of calcineurin 3.

Background: Calcineurin is a Ca(2+) dependent protein phosphatase that is involed in several neuornal functions. Proteins belonging to the RCAN (Regulator of calcineurin) family modulate the activity of Calcineurin through a valine-rich region within their carboxyl tail. RCANs compete with NFATs (Nuclear factor of activated T-cells) for binding to the same docking site in calcineurin, which results in either inhibition or activation of calcineurin activity. Calcipressin-2, also known as RCAN2 and DSCR1L1 (Down syndrome candidate region 1-like 1), is a 197 amino acid protein that is highly expressed in both the cytoplasm and nucleus of neurons and is the only RCAN family member that is found in glial cells. Calcipressin-3, also known as RCAN3 and DSCR1L2 (Down syndrome candidate region 1-like protein 2), is a 241 amino acid protein that potentially is involved in central nervous system development. Calcipressin-3 interacts with cardiac troponin I, suggesting that it may play a role in cardiac contraction events.