SNCA Antikörper (nTyr39)

Produktnummer ABIN1387711

Produktdetails anti-SNCA Antikörper

Target: SNCA (Synuclein, alpha (SNCA))

Bindungsspezifität: nTyr39

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNCA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic nitrylpeptide derived from human Alpha-synuclein around nitration site of Tyr39

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu SNCA

Target: SNCA (Synuclein, alpha (SNCA))

Andere Bezeichnung: alpha-Synuclein (SNCA Produkte)

Synonyme: snca antikoerper, MGC64356 antikoerper, LOC619283 antikoerper, NACP antikoerper, alphaSYN antikoerper, PARK1 antikoerper, PARK4 antikoerper, PD1 antikoerper, synuclein alpha L homeolog antikoerper, alpha-synuclein antikoerper, synuclein alpha antikoerper, synuclein, alpha antikoerper, snca.L antikoerper, LOC619283 antikoerper, SNCA antikoerper, Snca antikoerper

Hintergrund:

Synonyms: SYUA_HUMAN, nitrated Alpha-synuclein nitrated-Tyr39, nitrated Alpha-synuclein nitro-Tyr39, Alpha-synuclein nitro-Tyr39, Alpha-synuclein nitro Tyr39, nitrated Alpha synuclein, nitrated Alpha-Synuclein, Alpha synuclein, Alpha-synuclein, isoform NACP140, alphaSYN, MGC105443, MGC110988, MGC127560, MGC64356, NACP, Non A beta component of AD amyloid, Non A4 component of amyloid precursor, Non-A-beta component of alzheimers disease amyloid , precursor of, PARK 1, PARK 4, PARK1, PARK4, Parkinson disease familial 1, PD 1, PD1, SNCA, Snca synuclein, alpha non A4 component of amyloid precursor, Synuclein alpha, Synuclein, alpha non A4 component of amyloid precursor.

Background: The synuclein family members, including Alpha-synuclein (also designated NACP for non-Beta-Amyloid component) and Beta-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. Alpha-synuclein is localized to neuronal cell bodies and synapses. Alpha-synuclein was first identified as a component of Alzheimer?s disease amyloid plaques. Abnormal platelet function in Alzheimer?s disease has been demonstrated. During megakaryocytic differentiation Alpha-synuclein has been found to be upregulated, while Beta-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of Alpha-synuclein has been found in patients with early onset Parkinson?s disease.

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity