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Progestin Receptor beta/mprb (AA 251-300) Antikörper

Reaktivität: Hund, Maus, Ratte, Schaf ELISA, ICC, IF (cc), IF (p), IHC (fro), IHC (p), WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1387676
  • Target
    Progestin Receptor beta/mprb
    Bindungsspezifität
    AA 251-300
    Reaktivität
    Hund, Maus, Ratte, Schaf
    Wirt
    Kaninchen
    Klonalität
    Polyklonal
    Applikation
    ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Kreuzreaktivität
    Hund, Maus, Ratte, Schaf
    Homologie
    Human,Cow,Pig,Horse,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Progestin Receptor Beta
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Kasubuchi, Watanabe, Hirano, Inoue, Li, Terasawa, Konishi, Itoh, Kimura: "Membrane progesterone receptor beta (mPRβ/Paqr8) promotes progesterone-dependent neurite outgrowth in PC12 neuronal cells via non-G protein-coupled receptor (GPCR) signaling." in: Scientific reports, Vol. 7, Issue 1, pp. 5168, (2017) (PubMed).

  • Target
    Progestin Receptor beta/mprb
    Hintergrund

    Synonyms: C6orf33, LMPB1, Lysosomal membrane protein in brain 1, Membrane progestin receptor beta, mPR beta, MPRB, PAQR8, Progestin and adipoQ receptor family member 8, Progestin and adipoQ receptor family member VIII, MPRB_HUMAN.

    Background: The steroid progesterone induces the resumption of maturation in oocytes via a nongenomic pathway through binding to a novel membrane progestin receptor (mPR). This pathway inhibits adenylyl cyclase and reduces intracellular cAMP, and also activates mitogen-activated protein kinase to effect signal transduction pathways. Five distinct groups, designated Alpha, Beta, Gamma, Delta, comprise the mPR gene family. mPR Alpha, also designated progestin and adipo Theta receptor family member VII (PAQR7), consists of an extracellular N-terminus, an intracellular C-terminus and seven transmembrane domains. mPR Alpha is expressed in ovary, testis, placenta, uterus and bladder. mPR Beta, or progestin and adipo Theta receptor family member VIII (PAQR8), consists of eight putative transmembrane regions and an intracellular N-terminus that contains a leucine-rich motif. mPR Beta is a 354 amino acid protein expressed in brain and spinal cord. Both mPR Alpha and mPR Beta may be G protein-coupled receptors and may be involved in oocyte maturation.

    Gen-ID
    85315
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