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DAB1 Antikörper (AA 131-220)

Der Kaninchen Polyklonal Anti-DAB1-Antikörper wurde für ELISA, IF (cc), IF (p), IHC (p), ICC und IHC (fro) validiert. Er ist geeignet, DAB1 in Proben von Human zu detektieren.
Produktnummer ABIN1387520

Kurzübersicht für DAB1 Antikörper (AA 131-220) (ABIN1387520)

Target

Alle DAB1 Antikörper anzeigen
DAB1 (Disabled Homolog 1 (Drosophila) (DAB1))

Reaktivität

  • 62
  • 56
  • 56
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
Human

Wirt

  • 92
  • 4
  • 2
Kaninchen

Klonalität

  • 96
  • 2
Polyklonal

Konjugat

  • 43
  • 5
  • 5
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser DAB1 Antikörper ist unkonjugiert

Applikation

  • 71
  • 40
  • 40
  • 32
  • 21
  • 16
  • 12
  • 10
  • 8
  • 8
  • 2
  • 2
  • 1
  • 1
ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 15
    • 15
    • 15
    • 7
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 131-220

    Homologie

    Human,Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human Dab1

    Isotyp

    IgG
  • Applikationshinweise

    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Target

    DAB1 (Disabled Homolog 1 (Drosophila) (DAB1))

    Andere Bezeichnung

    Dab1

    Hintergrund

    Synonyms: Dab 1,Dab1,Dab-1,DAB1_HUMAN,Disabled homolog 1,Disabled homolog 1 Drosophila,Scm,Scr,Scrambler,Yot,Yotari.

    Background: Dab1, a homolog of the Drosophila Disabled protein, is an adaptor protein involved in neural development. This cytoplasmic protein is tyrosine-phosphorylated during rapid expansion of the developing nervous system, and it is thought to interact with other proteins via a domain similar to the PTB domains of the Shc family. Dab1 has been shown to interact with the SH2 domains of Src, Fyn and Abl (1). Mutations in Dab1 result in widespread abnormalities in the brain, similar to those seen in Reelin mutants (2). Reelin is a secreted protein thought to play a role in directing migrating neurons (3). Evidence suggests that Dab1 functions downstream of Reelin in a signaling pathway involved in positioning cells in the developing brain (4). Dab2 (also designated DOC-2) is a mitogen-responsive phosphoprotein that binds the SH3 domain of Grb2, and it is thought to be a negative regulator of growth (5).

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