TROVE2 Antikörper (AA 331-430)

Produktnummer ABIN1387451

Der Kaninchen Polyklonal Anti-TROVE2-Antikörper wurde für ELISA, IF (cc), IF (p), ICC, IHC (p) und IHC (fro) validiert. Er ist geeignet, TROVE2 in Proben von Human zu detektieren.

Kurzübersicht für TROVE2 Antikörper (AA 331-430) (ABIN1387451)

Target: TROVE2 (TROVE Domain Family, Member 2 (TROVE2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TROVE2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-TROVE2 Antikörper

Bindungsspezifität: AA 331-430

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TROVE-2/SSA2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu TROVE2

Target: TROVE2 (TROVE Domain Family, Member 2 (TROVE2))

Andere Bezeichnung: TROVE-2

Hintergrund:

Synonyms: TROVE2, 60 kDa ribonucleoprotein Ro, 60 kDa Ro protein, 60 kDa SS A/Ro ribonucleoprotein, 60 kDa SS-A/Ro ribonucleoprotein, Autoantigen Ro/SSA, 60-KD, bA101E13.2, Gastric cancer multi drug resistance protein, Ribonucleoprotein autoantigen SS A/Ro, RO 60, Ro 60 kDa autoantigen, RO60, RO60_HUMAN, RoRNP, Sjoegren syndrome antigen A2, Sjoegren syndrome type A antigen, Sjogren syndrome antigen A2 60kD ribonucleoprotein autoantigen SS A/Ro, Sjogren syndrome antigen A2 60 kDa ribonucleoprotein autoantigen SS A/Ro, Sjogren syndrome antigen A2, SS A, SS-A, SS-A/Ro, SSA 2, SSA, SSA2, TROVE 2, TROVE domain family member 2, TROVE2.

Background: Ro autoantigens are of clinical significance because directed against them are found in most patients with primary Sjqgren syndrome, subacute cutaneous lupus erythematosus (SLE), neonatal lupus erythematosus, ANA-negative lupus erythematosus, and systemic lupus erythematosus-like disease secondary to homozygous C2 or C4 complement deficiency (1). Ro/SSA is a ribonucleoprotein that binds to auto in 35 to 50 % of patients with SLE and in up to 97 % of patients with Sjqgren syndrome (2). The Ro/SSA particle consists of a single immunoreactive protein noncovalently bound with one of four small RNA molecules (2). Most anti-Ro/SSA-positive sera detect not only the main protein, but also a smaller Ro/SSA protein (2). The genes which encode the smaller and larger proteins map to human chromosomes 11p15.5 and 1q31, respectively (3?). La/SSB is an autoimmune RNA-binding protein that plays a role in the transcription of RNA polymerase III was originally defined by its reactivity with auto from patients with Sjren syndrome and SLE (6).