GUCA2A Antikörper (AA 22-115)

Produktnummer ABIN1387343

Der Kaninchen Polyklonal Anti-GUCA2A-Antikörper wurde für IF (cc), IF (p), ELISA, ICC, IHC (p) und IHC (fro) validiert. Er ist geeignet, GUCA2A in Proben von Human zu detektieren.

Kurzübersicht für GUCA2A Antikörper (AA 22-115) (ABIN1387343)

Target: GUCA2A (Guanylate Cyclase Activator 2A (Guanylin) (GUCA2A))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GUCA2A Antikörper ist unkonjugiert

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-GUCA2A Antikörper

Bindungsspezifität: AA 22-115

Homologie: Human,Cow,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Guanylin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu GUCA2A

Target: GUCA2A (Guanylate Cyclase Activator 2A (Guanylin) (GUCA2A))

Andere Bezeichnung: Guanylin

Hintergrund:

Synonyms: GapI, GCAP-I, Guanylate cyclase activating protein 1, Guanylate cyclase activator 2A guanylin 2 intestinal heat-stable, Guanylate cyclase activator 2A, Guanylate cyclase-activating protein 1, Guanylate cyclase-activating protein I, Guanylin, GUC2A_HUMAN, GUCA 2, GUCA2, GUCA2A, STARA.

Background: The family of guanylin regulatory peptides, including guanylin and uroguanylin, are strongly expressed in intestinal mucosa and regulate intestinal fluid secretion during digestion. Guanylins are also involved in acid neutralization and the regulation of membrane-bound guanylate cyclase signaling molecules. Guanylin and uroguanylin are secreted primarily in the stomach, intestine, and colon. Guanylin is also detected in plasma. Guanylin is an endogenous activator of intestinal guanylate cyclase. It stimulates intestinal guanylate cyclase through the same receptor binding region as the heat-stable enterotoxins. Gut enterochromaffin cells synthesize guanylin to be a prohormone of 115 amino acids which is then is processed to the molecular form of 94 amino acids. This 10 kDa form is found circulating in the blood.