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PUM1 Antikörper (AA 201-300)

PUM1 Reaktivität: Maus, Ratte WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1387238
  • Target Alle PUM1 Antikörper anzeigen
    PUM1 (Pumilio Homolog 1 (PUM1))
    Bindungsspezifität
    • 8
    • 8
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 201-300
    Reaktivität
    • 55
    • 16
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    Maus, Ratte
    Wirt
    • 49
    • 3
    • 2
    • 2
    Kaninchen
    Klonalität
    • 46
    • 10
    Polyklonal
    Konjugat
    • 27
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser PUM1 Antikörper ist unkonjugiert
    Applikation
    • 37
    • 22
    • 20
    • 8
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Maus, Ratte
    Homologie
    Human,Dog,Cow,Sheep,Pig,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Pumilio 1
    Isotyp
    IgG
    Top Product
    Discover our top product PUM1 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    PUM1 (Pumilio Homolog 1 (PUM1))
    Andere Bezeichnung
    Pumilio 1 (PUM1 Produkte)
    Synonyme
    fb96a03 antikoerper, pumilio1 antikoerper, si:ch211-285e16.1 antikoerper, wu:fb96a03 antikoerper, wu:fb96a08 antikoerper, zgc:63671 antikoerper, PUM1 antikoerper, DKFZp459K0627 antikoerper, AA517475 antikoerper, Pumm antikoerper, mKIAA0099 antikoerper, HSPUM antikoerper, PUMH antikoerper, PUMH1 antikoerper, PUML1 antikoerper, pumilio RNA-binding family member 1 antikoerper, pumilio RNA binding family member 1 antikoerper, pum1 antikoerper, PUM1 antikoerper, Pum1 antikoerper
    Hintergrund

    Synonyms: PUMH, HSPUM, PUMH1, PUML1, Pumilio homolog 1, Pumilio-1, PUM1, KIAA0099

    Background: Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE) (PubMed:21572425, PubMed:18328718, PubMed:21653694, PubMed:21397187). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation (PubMed:22955276). Also mediates deadenylation-independent repression by promoting accessibility of miRNAs (PubMed:18776931, PubMed:20818387, PubMed:20860814, PubMed:22345517). Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (PubMed:20818387). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (PubMed:22345517). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905). Plays a role in cytoplasmic sensing of viral infection (PubMed:25340845). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53. Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (By similarity).

    Gen-ID
    9698
    UniProt
    Q14671
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