BRMS1 Antikörper (AA 151-246)

Produktnummer ABIN1386878

Der Kaninchen Polyklonal Anti-BRMS1-Antikörper wurde für WB, ELISA, IF (cc), IF (p), ICC, IHC (p) und IHC (fro) validiert. Er ist geeignet, BRMS1 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für BRMS1 Antikörper (AA 151-246) (ABIN1386878)

Target: BRMS1 (Breast Cancer Metastasis Suppressor 1 (BRMS1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BRMS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-BRMS1 Antikörper

Bindungsspezifität: AA 151-246

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human BRMS1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu BRMS1

Target: BRMS1 (Breast Cancer Metastasis Suppressor 1 (BRMS1))

Andere Bezeichnung: BRMS1

Hintergrund:

Synonyms: Breast cancer metastasis suppressor 1, Breast cancer metastasis-suppressor 1, BRMS-1, BRMS1_HUMAN, DKFZp564A063, MGC95128, AV003220, AW554636.

Background: Breast cancer metastasis-suppressor 1 (BRMS1) is 246 amino acid protein that acts as a mediator of metastasis suppression in several types of cancer including ovarian, lung, bladder, and murine mammary. BRMS1 mRNA is expressed in various tissues, including ovary, prostate, testis, and colon, but the protein is primarily detected in term placenta. BRMS1 suppresses metastasis without inhibiting tumorigenicity by modifying several metastasis-associated phenotypes. BRMS1 may participate in transcriptional regulation by binding to the mSin3/histone deacetylase complex. The expression of BRMS1 in certain cells increases connexin Cx43 expression and reduces connexin Cx32 expression. This produces a gap junction that increases intercellular communication, similar to those found in normal breast tissue. BRMS1 is stabilized by Hsp90 and may inhibit NF-_B activity.