FBXO15 Antikörper (AA 101-200)

Produktnummer ABIN1386824

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-FBXO15 Antikörper wird verwendet zum Nachweis von FBXO15 in Proben von Maus und Ratte. Er wurde validiert für WB, ELISA, IF (cc), IF (p), IHC (p) und IHC (fro).

Kurzübersicht für FBXO15 Antikörper (AA 101-200) (ABIN1386824)

Target: FBXO15 (F-Box Protein 15 (FBXO15))

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXO15 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-FBXO15 Antikörper

Bindungsspezifität: AA 101-200

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Fbx15

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-FBXO15 Antikörper (ABIN1386824)

Chang, Hung, Zhang, Hsieh, Hsu, Ding: "A Novel Signature of CCNF-Associated E3 Ligases Collaborate and Counter Each Other in Breast Cancer." in: Cancers, Vol. 13, Issue 12, (2021) (PubMed).

Details zu FBXO15

Target: FBXO15 (F-Box Protein 15 (FBXO15))

Andere Bezeichnung: Fbx15

Hintergrund:

Synonyms: F box protein 15, F-box only protein 15, F-box protein 15, Fbxo15, MGC39671, FBX15_HUMAN.

Background: FBXO15, also known as FBX15, is a 434 amino acid protein that contains one C-terminal F-box domain and belongs to the F-box family of proteins. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-a and b-catenin, for degradation by the proteasome after ubiquitination. Via its F-box domain, FBXO15 can directly interact with Skp1 p19 and CUL-1. In addition, FBXO15 is a target of the transcription factor Oct-3/4, however, it does not appear to be essential for early development and fertility.

Gen-ID: 201456