ANK2 Antikörper (AA 1901-2100)

Produktnummer ABIN1386782

Der Kaninchen Polyklonal Anti-ANK2-Antikörper wurde für IHC (p), ELISA, IF (cc), IF (p) und IHC (fro) validiert. Er ist geeignet, ANK2 in Proben von Maus zu detektieren.

Kurzübersicht für ANK2 Antikörper (AA 1901-2100) (ABIN1386782)

Target: ANK2 (Ankyrin 2, Neuronal (ANK2))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ANK2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-ANK2 Antikörper

Bindungsspezifität: AA 1901-2100

Kreuzreaktivität: Maus

Homologie: Human,Rat,Cow,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Ankyrin B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu ANK2

Target: ANK2 (Ankyrin 2, Neuronal (ANK2))

Andere Bezeichnung: Ankyrin B

Hintergrund:

Synonyms: ANK-2, Ank2, ANK2_HUMAN, Ankyrin 2, Ankyrin 2 brain, Ankyrin B, Ankyrin nonerythroid, ANKYRIN, NEURONAL, Ankyrin-2, Ankyrin-B, Brain ankyrin, Non-erythroid ankyrin

Background: Members of the Ankyrin family of proteins mediate the attachment of integral membrane proteins to the cytoskeleton. ANK1, ANK2 and ANK3 genes encode for the proteins in this family, Ankyrin-1 (also designated Ankyrin R), Ankyrin B and Ankyrin G, respectively. The proteins are structured similarly each composed of an N-terminal domain with multiple ankyrin repeats, a highly conserved central spectrin binding domain, and C-terminal regulatory domains which are susceptible to the most variance. Both Ankyrin B and Ankyrin G are essential for normal neuronal functions. Ankyrin B, or brain Ankyrin is predominantly expressed in the plasma membrane of neurons as well as glial cells throughout the brain. Two transcripts have been described with alternative splicing resulting in additional isoforms. The Ankyrin B protein associates with the spectrin-actin network, mediates axon fasciculation, and stabilizes axon bundles. Ankyrin B is required for coordinated assembly of Na/Ca exchanger, Na/K ATPase, and inositol trisphosphate (InsP(3)) receptor at transverse-tubule/sarcoplasmic reticulum sites in cardiomyocytes.

Gen-ID: 287

Pathways: Cell-Cell Junction Organization