CASK Antikörper (AA 651-750)

Produktnummer ABIN1386520

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CASK in ELISA, IF (cc), IF (p), IHC (p), ICC und IHC (fro). Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für CASK Antikörper (AA 651-750) (ABIN1386520)

Target: CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CASK Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-CASK Antikörper

Bindungsspezifität: AA 651-750

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CASK

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu CASK

Target: CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))

Andere Bezeichnung: CASK

Hintergrund:

Synonyms: CAGH39, Caki, Calcium/calmodulin dependent serine protein kinase, Calcium/calmodulin dependent serine protein kinase MAGUK family, Calcium/calmodulin dependent serine protein kinase membrane associated guanylate kinase, Calcium/calmodulin-dependent serine protein kinase, CAMGUK, CAMGUK protein, CAMGUK, drosophila, homolog of antibody casK, CMG, CSKP_HUMAN, DXPri1, DXRib1, FGS4, hCASK, LIN 2, Lin 2 homolog, LIN2 antibody Lin2 homolog, MICPCH, MRXSNA, Pals3, Peripheral plasma membrane protein CASK, Protein lin-2 homolog, TNRC8, Trinucleotide repeat containing 8, Vertebtate LIN2 homolog.

Background: The MAGUK (membrane-associated guanylate kinase homologs) family of proteins contain multiple protein-binding domains and are involved in cell junction organization, tumor suppression, and signaling. CASK (also designated LIN-2) belongs to a MAGUK subfamily which is characterized by a novel domain structure that consists of a calcium/calmodulin- dependent protein kinase domain followed by PDZ, SH3 and guanylate kinase-like (GUK) domains. CASK is expressed in rat brain where it binds to cell-surface proteins, such as neurexin and syndecan, and is thought to be involved in signaling at neuronal synapses. CASK translocates to the nucleus and interacts with Tbr-1 to form a complex, which binds to a specific DNA sequence (the T-element), and induces the expression of specific genes, including Reelin. CASK displays a transcription regulation function, which appears crucial for cerebrocortical development.

Pathways: Synaptic Vesicle Exocytosis