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OTUB1 Antikörper (AA 51-150)

Dieses Anti-OTUB1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von OTUB1 in WB, ELISA, ICC, IF (cc), IF (p), IHC (p) und IHC (fro). Geeignet für Human.
Produktnummer ABIN1386321

Kurzübersicht für OTUB1 Antikörper (AA 51-150) (ABIN1386321)

Target

Alle OTUB1 Antikörper anzeigen
OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))

Reaktivität

  • 62
  • 33
  • 19
  • 6
  • 5
  • 5
  • 5
  • 4
  • 3
  • 2
Human

Wirt

  • 73
  • 7
  • 1
Kaninchen

Klonalität

  • 73
  • 8
Polyklonal

Konjugat

  • 39
  • 13
  • 10
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser OTUB1 Antikörper ist unkonjugiert

Applikation

  • 70
  • 30
  • 20
  • 17
  • 12
  • 12
  • 12
  • 10
  • 5
  • 4
  • 3
  • 2
  • 1
Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 14
    • 13
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 51-150

    Homologie

    Human,Mouse,Rat,Dog,Cow,Sheep,Horse

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human OTUB1

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Target

    OTUB1 (OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1))

    Andere Bezeichnung

    OTUB1

    Hintergrund

    Synonyms: Deubiquitinating enzyme OTUB1, hOTU1, OTB1, OTU domain containing ubiquitin aldehyde binding protein 1, OTU domain-containing ubiquitin aldehyde-binding protein 1, OTU1, Otub1, OTUB1_HUMAN, Otubain 1, Otubain-1, Ubiquitin specic processing protease OTUB1, Ubiquitin thioesterase OTUB1, Ubiquitin-specic-processing protease OTUB1.

    Background: OTUB1 is a 271 amino acid protein that contains one OTU (ovarian tumor) domain and belongs to the OTU family of predicted cysteine proteases. Expressed as two isoforms (one of which is present throughout the body and the other of which is present only in lymphoid tissues), OTUB1 functions as a hydrolase that can remove ubiquitin residues from target proteins, thereby preventing protein degradation and playing an important role in protein turnover. OTUB1 interacts with GRAIL and, via this interaction, plays a role in the regulation and the induction of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to their cognate antigens. Due to its interaction with GRAIL, OTUB1 is an important regulator of immune responses in secondary lymphoid organs.

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