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JARID2 Antikörper (AA 301-400)

Der Kaninchen Polyklonal Anti-JARID2-Antikörper wurde für WB, ELISA, IF (cc), IF (p), ICC, IHC (p) und IHC (fro) validiert. Er ist geeignet, JARID2 in Proben von Human und Ratte zu detektieren.
Produktnummer ABIN1386206

Kurzübersicht für JARID2 Antikörper (AA 301-400) (ABIN1386206)

Target

Alle JARID2 Antikörper anzeigen
JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))

Reaktivität

  • 42
  • 15
  • 9
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Ratte

Wirt

  • 33
  • 9
  • 2
  • 1
Kaninchen

Klonalität

  • 34
  • 11
Polyklonal

Konjugat

  • 20
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser JARID2 Antikörper ist unkonjugiert

Applikation

  • 30
  • 12
  • 12
  • 11
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 14
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 301-400

    Kreuzreaktivität

    Human, Ratte

    Homologie

    Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human Jarid2/Jumonji

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Target

    JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))

    Andere Bezeichnung

    Jarid2/Jumonji

    Hintergrund

    Synonyms: JMJ, Protein Jumonji, Jumonji/ARID domain-containing protein 2, JARID2

    Background: Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.

    Gen-ID

    3720

    UniProt

    Q92833

    Pathways

    Chromatin Binding
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