SLC25A12 Antikörper (AA 101-200)

Produktnummer ABIN1385908

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SLC25A12 in WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) und ICC. Es zeigt Reaktivität gegenüber Proben von Maus.

Kurzübersicht für SLC25A12 Antikörper (AA 101-200) (ABIN1385908)

Target: SLC25A12 (Slc25a12) (Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 (Slc25a12))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLC25A12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Produktdetails anti-SLC25A12 Antikörper

Bindungsspezifität: AA 101-200

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Cow,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SLC25A12/ARALAR

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu SLC25A12

Target: SLC25A12 (Slc25a12) (Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12 (Slc25a12))

Andere Bezeichnung: SLC25A12/ARALAR

Hintergrund:

Synonyms: AGC1, Araceli hiperlarga, ARALAR, ARALAR1, Calcium binding mitochondrial carrier superfamily member, Calcium-binding mitochondrial carrier protein Aralar1, CMC1_HUMAN, Mitochondrial aspartate glutamate carrier 1, SLC25A12, Solute carrier family 25 member 12, solute carrier family 25, member 12.

Background: Calcium signaling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli. Signaling begins with Ca(2+) entry in mitochondria via the Ca(2+) uniporter followed by Ca(2+) activation of three dehydrogenases in the mitochondrial matrix. ARALAR, the neuronal Ca(2+)-binding mitochondrial aspartate-glutamate carrier, has Ca(2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS). ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle. ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation. It is also essential for the transmission of small Ca(2+) signals to mitochondria via an increase in mitochondrial NADH. In addition, ARALAR is implicated in conferring susceptibility to schizophrenia.

Pathways: Ribonucleoside Biosynthetic Process, Dicarboxylic Acid Transport