FOXC2 Antikörper

Produktnummer ABIN1385810

Der Kaninchen Polyklonal Anti-FOXC2-Antikörper wurde für WB, IHC (p) und IF (p) validiert. Er ist geeignet, FOXC2 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für FOXC2 Antikörper (ABIN1385810)

Target: FOXC2 (Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1) (FOXC2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FOXC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-FOXC2 Antikörper

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FOX C2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu FOXC2

Target: FOXC2 (Forkhead Box C2 (MFH-1, Mesenchyme Forkhead 1) (FOXC2))

Andere Bezeichnung: FOX C2

Hintergrund:

Synonyms: Drosphilia Forkhead Homolog Like 14, Drosphilia Forkhead Homolog Like 14, FKHL 14, FKHL 14, FKHL14, Forkhead Box C2, Forkhead Box C2, Forkhead box protein C2, Forkhead related protein FKHL14, Forkhead-related protein FKHL14, FOX C2, Foxc2, FOXC2_HUMAN, LD, Mesenchyme fork head protein 1, Mesenchyme Forkhead 1, Mesenchyme Forkhead 1, MFH 1, MFH 1, MFH 1 protein, MFH-1 protein, MFH1, Transcription factor FKH 14, Transcription factor FKH-14.

Background: FOXC2 is a member of forkhead/winged helix transcription factor family, whose members serve as key regulators in embryogenesis and cell differentiation (3). FOXC2 functions as a key regulator of adipocyte metabolism by increasing the sensitivity of the beta-adrenergic-cAMP-protein kinase A (PKA) signaling pathway through alteration of adipocyte PKA holoenzyme composition (4). Increased FOXC2 levels, induced by high fat diet, seem to counteract most of the symptoms associated with obesity (4). FOXC2 expression is also associated with the early stage of chondrogenic differentiation both in vivo and in vitro (3). FOXC2 haploinsufficiency results in Lymphedema-distichiasis (LD), an autosomal dominant disorder that classically presents as lymphedema of the limbs, and double rows of eyelashes (distichiasis) (5). Mutant mice null for FOXC2 show defects in axial and cranial skeletogenesis, suggesting a requirement of FOXC2 for skeletal tissue development (3). FOXC2 interacts with FOXC1 in the Notch signaling pathway (1) and in kidney and heart development (2).