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DIS3L Antikörper

DIS3L Reaktivität: Human, Maus, Ratte WB, IF (p), IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1385653
  • Target Alle DIS3L Antikörper anzeigen
    DIS3L (DIS3-Like Exonuclease 1 (DIS3L))
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 34
    • 3
    Kaninchen
    Klonalität
    • 37
    Polyklonal
    Konjugat
    • 9
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DIS3L Antikörper ist unkonjugiert
    Applikation
    • 32
    • 17
    • 14
    • 12
    • 4
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human DIS3L
    Isotyp
    IgG
    Top Product
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  • Applikationshinweise
    WB 1:300-5000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    DIS3L (DIS3-Like Exonuclease 1 (DIS3L))
    Andere Bezeichnung
    DIS3L (DIS3L Produkte)
    Synonyme
    DIS3L1 antikoerper, AV340375 antikoerper, RGD1308959 antikoerper, zgc:158615 antikoerper, DIS3 like exosome 3'-5' exoribonuclease antikoerper, DIS3-like exosome 3'-5' exoribonuclease antikoerper, DIS3L antikoerper, dis3l antikoerper, Dis3l antikoerper, dis3l.L antikoerper
    Hintergrund

    Synonyms: DIS3 like exonuclease 1, DIS3 mitotic control homolog S. cerevisiae like, FLJ38088, KIAA1955, MGC4562, DI3L1_HUMAN.

    Background: The exosome is a multi-protein complex composed of several highly conserved subunits, some of which are 3? to 5? exoribonucleases. The complex is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich elements (AREs) in their untranslated 3? regions. DIS3, also known as RRP44, is a 958 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one PINc domain. Widely expressed with highest expression in testis, DIS3 functions as a component of the exosome exoribonuclease complex and is required for processing of 7S pre-RNA into a mature nuclear complex and, ultimately, for proper mitotic progression. Abnormal expression levels of DIS3 may be associated with colon cancer, suggesting a role for DIS3 in tumorigenesis. Multiple isoforms of DIS3 exist due to alternative splicing events.

    Gen-ID
    115752
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