FIG4 Antikörper (AA 1-100)

Produktnummer ABIN1385590

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch FIG4 in WB, IF (cc), IF (p), IHC (p) und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für FIG4 Antikörper (AA 1-100) (ABIN1385590)

Target: FIG4 (FIG4 Homolog, SAC1 Lipid Phosphatase Domain Containing (FIG4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FIG4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-FIG4 Antikörper

Bindungsspezifität: AA 1-100

Verwendungszweck: FIG4 Polyclonal Antibody

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Dog,Sheep,Pig,Chicken,Monkey

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human FIG4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB(1:300-5000),

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu FIG4

Target: FIG4 (FIG4 Homolog, SAC1 Lipid Phosphatase Domain Containing (FIG4))

Andere Bezeichnung: FIG4/SAC3

Hintergrund:

Synonyms: 5-bisphosphate 5-phosphatase, Fig4, FIG4_HUMAN, KIAA0274, ALS11, Phosphatidylinositol 3, hSac3, Phosphatidylinositol 3,5 bisphosphate 5 phosphatase, Polyphosphoinositide phosphatase, SAC domain containing protein 3, SAC domain-containing protein 3, SAC3.

Background: FIG4 is a 907 amino acid protein that contains one SAC domain through which it is thought to function as a phosphoinositide phosphatase that may play an important role in signal transduction and vesicle trafficking. Defects in the gene encoding FIG4 are the cause of Charcot-Marie-Tooth disease type 4J (CMT4J) and amyotrophic lateral sclerosis type 11 (ALS11), both of which negatively affect the nervous system. CMT4J is a recessive demyelinating disorder of the peripheral nervous system and is characterized by reduced motor nerve conduction velocities and axonal degeneration. Unlike CMT4J, ALS11 is characterized by the degeneration of upper motor neurons in the brain and lower neurons in the spinal cord, causing paralysis and, ultimately, death.

Pathways: Inositol Metabolic Process