Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2) (AA 401-497) Antikörper

Produktnummer ABIN1385561

Der Kaninchen Polyklonal Anti- Antikörper wurde für IF (cc), IF (p), ELISA, IHC (fro) und IHC (p) validiert. Er ist geeignet, in Proben von Human und Virus zu detektieren.

Kurzübersicht für Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2) (AA 401-497) Antikörper (ABIN1385561)

Target: Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2)

Reaktivität: Human, Virus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails

Bindungsspezifität: AA 401-497

Kreuzreaktivität: Human, Virus

Kreuzreaktivität (Details): HHV4t2

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from HHV4t2 LMP2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: Epstein-Barr Virus Latent Membrane Protein 2 (EBV LMP2)

Andere Bezeichnung: EBV LMP2

Substanzklasse: Viral Protein

Hintergrund:

Synonyms: EBV latent membrane protein 2A, Epstein Barr virus, HHV4, Human Herpesvirus 4, Latent membrane protein 2, LMP2, Terminal protein, EBV LMP2A, LMP2_EBVB9 , Latent membrane protein 2B, EBV LMP2B.

Background: Epstein Barr virus (EBV) is a member of the herpesvirus family and one of the most common human viruses. Most people become infected with EBV during their lives. Primary infections usually results in infectious mononucleosis (glandular fever) but the virus can also lay dormant in B lymphocytes and when reactivated become associated with more serious disease such as Burkitt's lymphoma, nasopharyngeal carcinoma and Hodgkin's disease. EBV latently infects B lymphocytes. Infected B cells express EBV nuclear antigens and latent proteins LMP1, LMP2A and LMP2B. LMP2A forms aggregates in the plasma membranes of B lymphocytes, where it functions as a negative regulator of the Src and Syk protein tyrosine kinases. Studies show that LMP2A blocks B-cell receptor (BCR) signal transduction in EBV immortalized B cells in vitro and may play an important role in maintaining a latent EBV infection within the peripheral blood B cells of infected individuals.