CECR1 Antikörper (AA 450-500)

Produktnummer ABIN1385331

Produktdetails anti-CECR1 Antikörper

Target: CECR1 (Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1))

Bindungsspezifität: AA 450-500

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CECR1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CECR1/ADGF

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu CECR1

Target: CECR1 (Cat Eye Syndrome Chromosome Region, Candidate 1 (CECR1))

Andere Bezeichnung: CECR1 (CECR1 Produkte)

Synonyme: cecr1 antikoerper, fj65e02 antikoerper, wu:fj65e02 antikoerper, CECR1 antikoerper, ADA2 antikoerper, ADGF antikoerper, IDGFL antikoerper, adenosine deaminase 2a antikoerper, cat eye syndrome chromosome region, candidate 1 antikoerper, adenosine deaminase 2 antikoerper, adenosine deaminase 2 L homeolog antikoerper, ada2a antikoerper, CECR1 antikoerper, ADA2 antikoerper, ada2.L antikoerper

Hintergrund:

Synonyms: ADGF, Cat eye syndrome chromosome region candidate 1, Cat eye syndrome critical region protein 1, Cat eye syndrome critical region protein 1 precursor, CECR 1, IDGFL, CECR1_HUMAN.

Background: CECR1 is a member of the adenosine and AMP deaminases family. It may act as a growth factor and have adenosine deaminase activity. It is a candidate gene for cat eye syndrome. Two transcript variants encoding distinct isoforms have been identified for this gene.Adenosine deaminase is an enzyme that is present in most tissues and exists predominantly as a monomer, although in some tissues it is associated with adenosine deaminase-binding protein. Adenosine deaminase degrades extracellular adenosine, which is toxic for lymphocytes. A novel family of growth factors that share sequence similarity to adenosine deaminase has been identified. The cat eye syndrome critical region protein (CECR) family includes CECR1, CECR2, CECR3, CECR4, CECR5, CECR6, CECR7, CECR8 and CECR9. The genes encoding CECR proteins are candidates for Cat Eye Syndrome (CES), a developmental disorder associated with the duplication of a 2 Mb region of 22q11.2. CES is characterized by the combination of coloboma of the iris and anal atresia with fistula, downslanting palpebral fissures, preauricular tags and/or pits, frequent occurrence of heart and renal malformations, and normal or near-normal mental development. CECR family members are widely expressed. Specifically, CECR1 has the highest expression in adult heart, lung, lymphoblasts and placenta. CECR2 is also involved in neurulation and chromatin remodeling. Mutations in the CECR2 gene result in neural tube defects.

Gen-ID: 51816

UniProt: Q9NZK5

Pathways: Ribonucleoside Biosynthetic Process