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Humanin Antikörper (AA 1-24)

Der Kaninchen Polyklonal Anti-Humanin-Antikörper wurde für ELISA, IF (cc), IF (p), IHC (fro), IHC (p) und ICC validiert. Er ist geeignet, Humanin in Proben von Human zu detektieren.
Produktnummer ABIN1385204

Kurzübersicht für Humanin Antikörper (AA 1-24) (ABIN1385204)

Target

Humanin (MT-RNR2) (Mitochondrially Encoded 16S RNA (MT-RNR2))

Reaktivität

  • 24
  • 5
  • 3
Human

Wirt

  • 29
Kaninchen

Klonalität

  • 29
Polyklonal

Konjugat

  • 9
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Humanin Antikörper ist unkonjugiert

Applikation

  • 12
  • 12
  • 10
  • 7
  • 3
  • 3
  • 2
  • 2
  • 1
ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 15
    • 3
    • 1
    AA 1-24

    Homologie

    Human

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human Humanin

    Isotyp

    IgG
  • Applikationshinweise

    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Target

    Humanin (MT-RNR2) (Mitochondrially Encoded 16S RNA (MT-RNR2))

    Andere Bezeichnung

    Humanin

    Hintergrund

    Humanin, an endogenous anti-apoptotic peptide against Alzheimer disease-related insults, consists of 24 amino acids. The secreted protein is a neuroprotective factor against death induced by several different types of Alzheimer's disease genes. Humanin protects neuronal cells from damage caused by Alzheimer's disease genes, specifically APP (amyloid precursor protein). Humanin acts as a ligand for formyl peptide receptor-like 1 (FPRL1) with APP and utilizes its neuroprotective effects by inhibiting FPRL1 access to APP. The peptide prevents Bax translocation from cytosol to mitochondria. Humanin expression levels may be dependent on defects in energy production in muscles with mitochondrial abnormalities. The peptide has been detected in muscles of patients with the mitochondrial disease chronic progressive external ophthalmoplegia (CPEO). Humanin is mainly expressed in the kidney, heart, liver, testis and skeletal muscles.

    Subcellular location: Secreted

    Synonyms: HN,HUNIN, HUNIN_HUMAN.

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