GPRC5A Antikörper (AA 1-33)

Produktnummer ABIN1385196

Produktdetails anti-GPRC5A Antikörper

Target: GPRC5A (G Protein-Coupled Receptor, Family C, Group 5, Member A (GPRC5A))

Bindungsspezifität: AA 1-33

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GPRC5A Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RAI3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu GPRC5A

Target: GPRC5A (G Protein-Coupled Receptor, Family C, Group 5, Member A (GPRC5A))

Andere Bezeichnung: RAI3 (GPRC5A Produkte)

Synonyme: GPCR5A antikoerper, RAI3 antikoerper, RAIG1 antikoerper, Rai3 antikoerper, Raig1 antikoerper, G protein-coupled receptor class C group 5 member A antikoerper, G protein-coupled receptor, family C, group 5, member A antikoerper, G protein-coupled receptor, class C, group 5, member A antikoerper, GPRC5A antikoerper, Gprc5a antikoerper

Hintergrund:

Synonyms: G protein coupled receptor family C group 5 member A, G-protein coupled receptor family C group 5 member A, GPCR 5A, GPCR5A, Gprc 5a, Gprc5a, Orphan G protein coupling receptor PEIG 1, Orphan G protein coupling receptor PEIG1, Orphan G-protein-coupling receptor PEIG-1, RAI 3, RAI3_HUMAN, Raig 1, RAIG-1, Raig1, Retinoic acid induced 3, Retinoic acid induced gene 1 protein, Retinoic acid induced protein 3, Retinoic acid responsive, Retinoic acid responsive gene, Retinoic acid-induced gene 1 protein, Retinoic acid-induced protein 3.

Background: RAI3 is an transmembrane G-protein-coupled receptor that affects many essential biological processes including embryogenesis, cell growth, differentiation, and apoptosis. RAI3 may also be involved in maintaining homeostasis of epithelial cells. Retinoic acid receptors directly regulate RAI3 during its transcription in embryonal carcinoma differentiation. RAI3 expression is upregulated in most tumor cell lines that express mutant p53, suggesting that p53 interacts with the promoter of RAI3 and represses its expression at the beginning of apoptosis. RAI3 is a potential molecular target for diagnosing breast cancer, and selective suppression of signals from RAI3 may have a place in breast cancer treatments.