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SH3TC2 Antikörper (AA 851-950)

SH3TC2 Reaktivität: Human ELISA, WB, IF (cc), IF (p), IHC (p), IHC (fro), ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1385180
  • Target Alle SH3TC2 Antikörper anzeigen
    SH3TC2 (SH3 Domain and Tetratricopeptide Repeats 2 (SH3TC2))
    Bindungsspezifität
    • 14
    • 5
    • 1
    • 1
    AA 851-950
    Reaktivität
    • 21
    • 1
    Human
    Wirt
    • 21
    Kaninchen
    Klonalität
    • 21
    Polyklonal
    Konjugat
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SH3TC2 Antikörper ist unkonjugiert
    Applikation
    • 15
    • 12
    • 12
    • 8
    • 2
    • 2
    • 2
    • 1
    ELISA, Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    Homologie
    Human,Mouse,Rat,Cow,Pig,Horse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human SH3TC2
    Isotyp
    IgG
    Top Product
    Discover our top product SH3TC2 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    SH3TC2 (SH3 Domain and Tetratricopeptide Repeats 2 (SH3TC2))
    Andere Bezeichnung
    SH3TC2 (SH3TC2 Produkte)
    Synonyme
    CMT4C antikoerper, MNMN antikoerper, D430044G18Rik antikoerper, RGD1309038 antikoerper, SH3 domain and tetratricopeptide repeats 2 antikoerper, SH3TC2 antikoerper, Sh3tc2 antikoerper
    Hintergrund

    Synonyms: KIAA1985, CMT4C, D430044G18Rik, FLJ13605, MNMN, PP12494, RGD1309038, S3TC2_HUMAN, SH3 domain and tetratricopeptide repeats-containing protein 2, SH3TC2.

    Background: SH3TC2 (SH3 domain and tetratricopeptide repeats 2) is a 1,288 amino acid protein that contains one SH3 domain and eight TPR repeats. The SH3TC2 gene encodes a protein expressed in Schwann cells of peripheral nerves, and localized to the plasma membrane and to the perinuclear endocytic recycling compartment, suggesting a possible function in myelination and/or in regions of axoglial interactions. The SH3TC2 protein is expressed in adult heart, testis, spinal cord, and brain as well as in fetal brain and liver. Mild mononeuropathy of the median nerve (MNMN) is caused by heterozygous mutation in the SH3TC2 gene. Also, Charcot-Marie-Tooth disease type 4C (CMT4C) is a more severe neuropathy caused by homozygous or compound heterozygous mutation in the SH3TC2 gene. Existing as four alternatively spliced isoforms and containing 18 exons, the SH3TC2 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken and zebrafish, and maps to human chromosome 5q32.

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