ITGA4 Antikörper

Produktnummer ABIN135079

Dieser Ratte Monoklonal Antikörper detektiert spezifisch ITGA4 in FACS, IP, IHC (fro), BR und Adh Act. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für ITGA4 Antikörper (ABIN135079)

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Reaktivität: Human, Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser ITGA4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR), Adhesion Activation (Adh Act)

Klon: PS-2

Produktdetails anti-ITGA4 Antikörper

Verwendungszweck: Rat Anti-Mouse CD49d-LE/AF

Spezifität: Mouse/Human CD49d, Mr 150 kDa

Produktmerkmale: Low Endotoxin/Azide Free Anti-Mouse CD49d antibody for use in flow cytometry, immunohistochemistry, immunoprecipitation, blocking, and adhesion assays.

Endotoxin-Niveau: Low Endotoxin

Immunogen: P815 cells

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Konservierungsmittel: Azide free

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Informationen zur Lagerung: 2-8°C

Details zu ITGA4

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Andere Bezeichnung: CD49d

Hintergrund: CD49d, the 4 chain (100 kDa) of the VLA-4 integrin heterodimer (Mr 150 kDa) VLA-4 belongs to the 1-integrin family, which functions both as cell-matrix and cell-cell receptors.1-3 As a matrix receptor VLA-4 binds to an alternatively spliced domain of fibronectin, while as a cellular receptor it associates with its counter-receptor ligand VCAM-1. In addition to CD44/pgp-1, VLA-4 has been shown to be important for lymphopoiesis, and is also believed to be important for extravasation of lymphocytes into sites of inflammation as a second signal in addition to LFA/ICAM-1. CD49d/VLA-4 is expressed in low amounts on resting lymphocytes and monocytes, is absent or minimally detectable on stromal cells, whereas virtually all lymphoid and myeloid cells in bone marrow and in long-term culture are positive.

Gen-ID: 16401

UniProt: Q00651

Pathways: Integrin Complex