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CD16 Antikörper (CD16) (PE) Primary Antibody

CD16 Reaktivität: Human, Non-Human Primate FACS, Func, IHC (fro), IP Wirt: Maus Monoclonal 3G8 PE
Pubmed (6 references)
Produktnummer ABIN1303145
$484.24
Zzgl. Versandkosten $45.00
100 tests
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 5 bis 7 Werktagen
  • Target Alle CD16 Antikörper anzeigen
    CD16
    Reaktivität
    • 168
    • 42
    • 20
    • 18
    • 18
    • 10
    • 10
    • 8
    • 8
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Human, Non-Human Primate
    Wirt
    • 149
    • 41
    • 23
    • 1
    Maus
    Klonalität
    • 181
    • 31
    • 1
    Monoklonal
    Konjugat
    • 76
    • 26
    • 17
    • 17
    • 10
    • 9
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD16 Antikörper ist konjugiert mit PE
    Applikation
    • 177
    • 51
    • 43
    • 40
    • 31
    • 27
    • 27
    • 25
    • 8
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Flow Cytometry (FACS), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP)
    Spezifität
    The mouse monoclonal antibody 3G8 recognizes CD16, a low affinity receptor for aggregated IgG (FcgammaRIII antigen). CD16 exists in two different isoforms: CD16a (FcgammaRIIIA, 50-65 kDa, expressed on NK-cells, monocytes and macrophages) and CD16b (FcgammaRIIIB, 48 kDa, mainly expressed on neutrophils).

    HLDA V, WS Code NK80
    Kreuzreaktivität (Details)
    Human, Non-Human Primates
    Immunogen
    Human neutrophils
    Klon
    3G8
    Isotyp
    IgG1
  • Applikationshinweise
    The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μ,l reagent / 100 μ,l of whole blood or 106 cells in a suspension.The content of a vial (2 ml) is sufficient for 100 tests.
    Kommentare

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    No reconstitution is necessary.
    Buffer
    The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide.
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Avoid prolonged exposure to light.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
  • Burt, Plitas, Zhao, Bamboat, Nguyen, Dupont, DeMatteo: "The lytic potential of human liver NK cells is restricted by their limited expression of inhibitory killer Ig-like receptors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 3, pp. 1789-96, (2009) (PubMed).

    Choi, Wang, Peterson, Letvin, Reimann: "Use of an anti-CD16 antibody for in vivo depletion of natural killer cells in rhesus macaques." in: Immunology, Vol. 124, Issue 2, pp. 215-22, (2008) (PubMed).

    Congy-Jolivet, Bolzec, Ternant, Ohresser, Watier, Thibault: "Fc gamma RIIIa expression is not increased on natural killer cells expressing the Fc gamma RIIIa-158V allotype." in: Cancer research, Vol. 68, Issue 4, pp. 976-80, (2008) (PubMed).

    Komano, Nanki, Hayashida, Taniguchi, Miyasaka: "Identification of a human peripheral blood monocyte subset that differentiates into osteoclasts." in: Arthritis research & therapy, Vol. 8, Issue 5, pp. R152, (2007) (PubMed).

    Wijngaarden, van Roon, van de Winkel, Bijlsma, Lafeber: "Down-regulation of activating Fcgamma receptors on monocytes of patients with rheumatoid arthritis upon methotrexate treatment." in: Rheumatology (Oxford, England), Vol. 44, Issue 6, pp. 729-34, (2005) (PubMed).

    Metes, Ernst, Chambers, Sulica, Herberman, Morel: "Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene." in: Blood, Vol. 91, Issue 7, pp. 2369-80, (1998) (PubMed).

  • Target
    CD16
    Andere Bezeichnung
    CD16 (CD16 Produkte)
    Synonyme
    Fcgr3, Fcgr3a, CD16, FCGR3, FCGR3@, CD16b, FCG3, FCR-10, FCRIII, FCRIIIb, FcRIII, Fc fragment of IgG, low affinity IIa, receptor, Fc fragment of IgG, low affinity IIIa, receptor (CD16a), Fc fragment of IgG receptor IIIb, Fc fragment of IgG receptor IIIa, Fc receptor, IgG, low affinity III, Fc-gamma RIII, Fcgr2a, FCGR3A, FCGR3B, Fcgr3, FCGR3
    Hintergrund
    CD16 (FcgammaRIII) is a 50-65 kDa glycoprotein serving as a low affinity IgG receptor. Human FcgammaRIII is expressed in two forms –, FcgammaRIII-A and -B. FcgammaRIII-A is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. It is associated with FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FcgammaRIII-A is associated, moreover, with FcepsilonRI-beta subunit. Besides IgG, FcgammaRIII-A can be triggered also by oligomeric IgE. FcgammaRIII-B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype.
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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