CD163 Antikörper (APC)

Produktnummer ABIN1302642

Dieses Anti-CD163-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von CD163 in FACS. Geeignet für Human. Dieses Primary Antibody wurde in 5+ Publikationen zitiert.

Kurzübersicht für CD163 Antikörper (APC) (ABIN1302642)

Target: CD163

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD163 Antikörper ist konjugiert mit APC

Applikation: Flow Cytometry (FACS)

Klon: GHI-61

Produktdetails anti-CD163 Antikörper (APC)

Verwendungszweck: Anti-Hu CD163 APC

Spezifität: The mouse monoclonal antibody GHI/61 recognizes an extracellular epitope CD163, an approximately 130 kDa high affinity scavenger receptor expressed mainly on monocytes and macrophages, which binds hemoglobin-haptoglobin complex.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: Hairy cell leukemia cells

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: No reconstitution is necessary.

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.
Avoid prolonged exposure to light.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Referenzen für anti-CD163 Antikörper (APC) (ABIN1302642)

Kusi, Gyan, Goka, Dodoo, Obeng-Adjei, Troye-Blomberg, Akanmori, Adjimani: "Levels of soluble CD163 and severity of malaria in children in Ghana." in: Clinical and vaccine immunology : CVI, Vol. 15, Issue 9, pp. 1456-60, (2008) (PubMed).

Moniuszko, Kowal, Rusak, Pietruczuk, Dabrowska, Bodzenta-Lukaszyk: "Monocyte CD163 and CD36 expression in human whole blood and isolated mononuclear cell samples: influence of different anticoagulants." in: Clinical and vaccine immunology : CVI, Vol. 13, Issue 6, pp. 704-7, (2006) (PubMed).

Kim, Alvarez, Fisher, Bronfin, Westmoreland, McLaurin, Williams: "CD163 identifies perivascular macrophages in normal and viral encephalitic brains and potential precursors to perivascular macrophages in blood." in: The American journal of pathology, Vol. 168, Issue 3, pp. 822-34, (2006) (PubMed).

Law, Micklem, Shaw, Zhang, Dong, Willis, Mason: "A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily." in: European journal of immunology, Vol. 23, Issue 9, pp. 2320-5, (1993) (PubMed).

Pulford, Micklem, McCarthy, Cordell, Jones, Mason: "A monocyte/macrophage antigen recognized by the four antibodies GHI/61, Ber-MAC3, Ki-M8 and SM4." in: Immunology, Vol. 75, Issue 4, pp. 588-95, (1992) (PubMed).

Details zu CD163

Target: CD163

Andere Bezeichnung: CD163

Hintergrund: CD163 Molecule,CD163, also known as M130, is a member of the scavenger receptor family, accounting for the clearance of hemoglobin-haptoglobin complexes during limited hemolysis, which protects the body, in particular the kidneys, against heme-mediated oxidative damages. It does not have measurable affinity for noncomplexed hemoglobin or haptoglobin. Immunomodulatory role of CD163 has been postulated. CD163 is expressed by cells of the monocyte-macrophage lineage and its extracellular part also circulates in plasma as a soluble protein, especially during sepsis and other conditions affecting macrophage activity, when its level may raise manyfold.,MM130, SCARI1

Gen-ID: 9332

UniProt: Q86VB7