ABCB6 Antikörper (AA 430-465)
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- Target Alle ABCB6 Antikörper anzeigen
- ABCB6 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 6 (ABCB6))
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Bindungsspezifität
- AA 430-465
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Reaktivität
- Human, Hund
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ABCB6 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Hersteller Produkt- Nr.
- 600-401-945
- Hersteller
- Rockland
- Verwendungszweck
- ABCB6 Antibody
- Kreuzreaktivität (Details)
- This affinity-purified antibody is directed against human ABCB6 protein.
- Produktmerkmale
- Synonyms: rabbit anti-ABCB6 Antibody, ABCB 6, ABCB-6, ABC transporter umat antibody, ABC14 antibody, ATP binding cassette sub family B member 6, mitochondrial precursor antibody, mitochondrial precursor ABC transporter 3, Mt-ABC transporter 3
- Aufreinigung
- The product was affinity purified from monospecific antiserum by immunoaffinity purification.
- Sterilität
- Sterile filtered
- Immunogen
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Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region near amino acids 430-465 of human ABCB6 protein.
Immunogen Type: Conjugated Peptide
- Isotyp
- IgG
- Top Product
- Discover our top product ABCB6 Primärantikörper
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- Applikationshinweise
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Application Note: This affinity-purified antibody has been tested for use in ELISA and western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 94 kDa in size corresponding to ABCB6 protein by western blotting in the appropriate cell lysate or extract.
Western Blot Dilution: 1:1,000 - 1:5,000
ELISA Dilution: 1:40,000 - 1:130,000
Other: User Optimized
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1.0 mg/ml
- Buffer
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide - Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
- Haltbarkeit
- 12 months
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Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy." in: Scientific reports, Vol. 6, pp. 36478, (2016) (PubMed).
: "Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC) transporters ABCB6 and sulfonylurea receptor 1 (SUR1)/ABCC8." in: The Journal of biological chemistry, Vol. 286, Issue 10, pp. 8481-92, (2011) (PubMed).
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Dormant cancer cells accumulate high protoporphyrin IX levels and are sensitive to 5-aminolevulinic acid-based photodynamic therapy." in: Scientific reports, Vol. 6, pp. 36478, (2016) (PubMed).
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- Target
- ABCB6 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 6 (ABCB6))
- Andere Bezeichnung
- ABCB6 (ABCB6 Produkte)
- Hintergrund
- Background: This antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. ABCB6 (ATP-binding cassette sub-family B member 6) is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABCB6 is a membrane-associated protein that transports various molecules across the extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, DR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily confer multi-drug resistance (MDR) to cancer cells and are also involved in antigen presentation. ABCB6 also likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function. Anti-ABCB6 is ideal for researchers interested in heme synthesis.
- Gen-ID
- 10058, 13123949
- UniProt
- Q9NP58
- Pathways
- Transition Metal Ion Homeostasis
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