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Myosin Antikörper AA 12-27 Primary Antibody

Reaktivität: Human IP, IHC, ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
Pubmed (3 references)
Produktnummer ABIN129691
$658.50
Zzgl. Versandkosten $45.00 und $20.00 Trockeneis
100 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 1 bis 2 Werktagen
  • Target Alle Myosin Antikörper anzeigen
    Myosin
    Bindungsspezifität
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 12-27
    Reaktivität
    • 40
    • 13
    • 10
    • 7
    • 7
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 31
    • 16
    Kaninchen
    Klonalität
    • 31
    • 16
    Polyklonal
    Konjugat
    • 31
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Myosin Antikörper ist unkonjugiert
    Applikation
    • 28
    • 24
    • 18
    • 13
    • 8
    • 8
    • 5
    • 4
    • 2
    • 1
    Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Kreuzreaktivität
    Maus, Ratte (Rattus)
    Produktmerkmale
    Concentration Definition: by UV absorbance at 280 nm
    Immunogen
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 12-27 of human myosin light chain protein.
    Isotyp
    IgG
  • Applikationshinweise
    This affinity-purified antibody was tested by ELISA and immunoblotting and was found to be reactive with both the unphosphorylated and mono-phosphorylated forms of the protein.   Although not tested, this antibody is likely functional in immunohistochemistry and immunoprecipitation.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.71 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
  • Deng, Bhaidani, Sutherland, MacDonald, Walsh et al.: "Rho-associated kinase and zipper-interacting protein kinase, but not myosin light chain kinase, are involved in the regulation of myosin phosphorylation in serum-stimulated human arterial smooth ..." in: PLoS ONE, Vol. 14, Issue 12, pp. e0226406, (2020) (PubMed).

    Lahey, Ronaghan, Shang, Dion, Désilets, Leduc, MacNaughton: "Signaling pathways induced by serine proteases to increase intestinal epithelial barrier function." in: PLoS ONE, Vol. 12, Issue 7, pp. e0180259, (2017) (PubMed).

    Logue, Cartagena-Rivera, Baird, Davidson, Chadwick, Waterman: "Erk regulation of actin capping and bundling by Eps8 promotes cortex tension and leader bleb-based migration." in: eLife, Vol. 4, pp. e08314, (2016) (PubMed).

  • Target
    Myosin
    Abstract
    Myosin Produkte
    Synonyme
    CG3201, DmMLC_C, Dmel\\CG3201, MyoII, mlc-c, nmELC, MYOSIN, myosin 1, DFNA4, DFNA4A, MHC16, MYH17, NMHC II-C, NMHC-II-C, PNMHH, myosin, MYH1, MYH2, MYH3, MYH4, MYH8, adult, embryonic, 2400004E04Rik, II-C, NHMCII, DROMHC, Dm nmII, DmnmII, Dronm-MII, E(br), MHC, Mhc-c, Mhc-c[1], Myo, Myo II, NMM, Zip, anon-WO0140519.37, l(2)02957, nmMHC, nmy-2, zpr, DmelCG15792, CG15792, Myosin light chain cytoplasmic, hypothetical protein, myosin 1, myosin heavy chain 9, myosin heavy chain 14, myosin, heavy chain 1B, skeletal muscle, myosin, heavy polypeptide 14, zipper, Mlc-c, T22C1.6, ATM1, MYH9, MYH14, Myh14, MYH1B, zip
    Hintergrund
    Myosin is the major component of thick muscle filaments, and is a long asymmetric molecule containing a globular head and a long tail.  The molecule consists of two heavy chains each ~200,000 daltons, and four light chains each ~16,000 - 21,000 daltons.  Activation of smooth and cardiac muscle primarily involves pathways that increase calcium and myosin phosphorylation resulting in contraction.   Myosin light chain phosphatase acts to regulate muscle contraction by dephosphorylating activated myosin light chain.  The selected peptide sequence used to generate the polyclonal antibody is located near the amino terminal end of the polypeptide corresponding to the smooth/non-muscle form of myosin regulatory light chain found in cardiac myocytes in addition to smooth and non-muscle cells.  This sequence differs from that of the sarcomeric/
    Synonyms: Myosin regulatory light polypeptide 9 Myosin regulatory light chain 9 Myosin regulatory light chain MRLC1 Myosin regulatory light chain 2, smooth muscle isoform Myosin RLC MLC-2C 20 kDa myosin light chain
    Gen-ID
    98932, 38605043
    UniProt
    P24844
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