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alpha Tubulin Antikörper (TUBA1) Internal Region Primary Antibody

TUBA1 Reaktivität: Human, Maus, Ratte, Huhn, Rind (Kuh) ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
Pubmed (18 references)
Produktnummer ABIN129653
$547.50
Zzgl. Versandkosten $45.00 und $20.00 Trockeneis
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 1 bis 2 Werktagen
  • Target Alle alpha Tubulin (TUBA1) Antikörper anzeigen
    alpha Tubulin (TUBA1)
    Bindungsspezifität
    • 20
    • 12
    • 8
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 149
    • 107
    • 102
    • 32
    • 25
    • 23
    • 16
    • 16
    • 11
    • 9
    • 8
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Huhn, Rind (Kuh)
    Wirt
    • 88
    • 70
    • 13
    • 2
    • 2
    • 1
    • 1
    Kaninchen
    Klonalität
    • 110
    • 64
    • 2
    Polyklonal
    Konjugat
    • 111
    • 13
    • 9
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser alpha Tubulin Antikörper ist unkonjugiert
    Applikation
    • 149
    • 70
    • 64
    • 59
    • 59
    • 49
    • 41
    • 13
    • 10
    • 7
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Spezifität
    Anti-Tubulin Loading Control Antibody is directed against human alpha Tubulin protein. The Loading Control Antibody was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest that this antibody would react with alpha Tubulin from a wide range of organisms, including avian, mammalian aquatic, parasitic and alga sources based on 100% homology for the immunogen sequence. Cross reactivity will occur with all isoforms of alpha tubulin. Such broad reactivity makes this antibody useful as an excellent loading control.
    Produktmerkmale
    Tubulin Loading Control Antibody recognizes microtubules which are involved in a wide variety of cellular activities ranging from mitosis and transport events to cell movement and the maintenance of cell shape. Tubulin itself is a globular protein consisting of two polypeptides (alpha and beta tubulin). Alpha and beta tubulin dimers are assembled to 13 protofilaments that form a microtubule of 22-nm diameter. Tyrosine ligase adds a C-terminal tyrosine to monomeric alpha tubulin. Assembled microtubules can again be detyrosinated by a cytoskeleton-associated carboxypeptidase. Detyrosinated alpha tubulin is referred to as Glu-tubulin. Another post-translational modification of detyrosinated alpha tubulin is C-terminal polyglutamylation, which is characteristic of microtubules in neuronal cells and the mitotic spindle. This antibody makes an excellent loading control.
    Sterilität
    Sterile filtered
    Immunogen
    Anti-Tubulin Loading Control Antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 427-441 of Human alpha Tubulin.
    Immunogen Type: Peptide
    Isotyp
    IgG
  • Applikationshinweise
    Anti-Tubulin Antibody has been tested for use in ELISA and western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band at ~50 kDa in size corresponding to alpha tubulin by western blotting in most cell lysates or extracts.
    Kommentare

    Gene Name: TUBA1B

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.1 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
    Haltbarkeit
    12 months
  • Garland, Comet, Wu, Radzisheuskaya, Rib, Vitting-Seerup, Lloret-Llinares, Sandelin, Helin, Jensen: "A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2." in: Cell reports, Vol. 29, Issue 7, pp. 1800-1811.e6, (2019) (PubMed).

    Kim, Kim: "Effect of HIV-1 Tat on the formation of the mitotic spindle by interaction with ribosomal protein S3." in: Scientific reports, Vol. 8, Issue 1, pp. 8680, (2018) (PubMed).

    Brown, Dayan, Wong, Kaczmarek, Hope, Pederson, Arnet, Goodall, Russell, Sadlon, Barry: "FOXP3 and miR-155 cooperate to control the invasive potential of human breast cancer cells by down regulating ZEB2 independently of ZEB1." in: Oncotarget, Vol. 9, Issue 45, pp. 27708-27727, (2018) (PubMed).

    Lloret-Llinares, Karadoulama, Chen, Wojenski, Villafano, Bornholdt, Andersson, Core, Sandelin, Jensen: "The RNA exosome contributes to gene expression regulation during stem cell differentiation." in: Nucleic acids research, Vol. 46, Issue 21, pp. 11502-11513, (2018) (PubMed).

    Ghosh, Abdelwahab, Reeber, Reidel, Marklew, Garrison, Lee, Dang, Herring, Glish, Kesimer, Tarran: "Little Cigars are More Toxic than Cigarettes and Uniquely Change the Airway Gene and Protein Expression." in: Scientific reports, Vol. 7, pp. 46239, (2018) (PubMed).

    Kapadia, Bijelić, Zhao, Ma, Stojanovich, Milošević, Andjus, Šakić: "Effects of sustained i.c.v. infusion of lupus CSF and autoantibodies on behavioral phenotype and neuronal calcium signaling." in: Acta neuropathologica communications, Vol. 5, Issue 1, pp. 70, (2018) (PubMed).

    Liao, Ren, Peterson, Marshak, Yau, Gamlin, Dacey: "Melanopsin-expressing ganglion cells on macaque and human retinas form two morphologically distinct populations." in: The Journal of comparative neurology, Vol. 524, Issue 14, pp. 2845-72, (2017) (PubMed).

    Dilworth, Upadhyay, Bonnafous, Edoo, Bourbigot, Pesek-Jardim, Gudavicius, Serpa, Petrotchenko, Borchers, Nelson, Mackereth: "The basic tilted helix bundle domain of the prolyl isomerase FKBP25 is a novel double-stranded RNA binding module." in: Nucleic acids research, Vol. 45, Issue 20, pp. 11989-12004, (2017) (PubMed).

    Lloret-Llinares, Mapendano, Martlev, Lykke-Andersen, Jensen: "Relationships between PROMPT and gene expression." in: RNA biology, Vol. 13, Issue 1, pp. 6-14, (2016) (PubMed).

    Li, Dou, Li, Zhang, Zeng, Song: "Nicotinamide ameliorates palmitate-induced ER stress in hepatocytes via cAMP/PKA/CREB pathway-dependent Sirt1 upregulation." in: Biochimica et biophysica acta, Vol. 1853, Issue 11 Pt A, pp. 2929-36, (2015) (PubMed).

    Besche, Sha, Kukushkin, Peth, Hock, Kim, Gygi, Gutierrez, Liao, Dick, Goldberg: "Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates." in: The EMBO journal, Vol. 33, Issue 10, pp. 1159-76, (2014) (PubMed).

    Gudavicius, Dilworth, Serpa, Sessler, Petrotchenko, Borchers, Nelson: "The prolyl isomerase, FKBP25, interacts with RNA-engaged nucleolin and the pre-60S ribosomal subunit." in: RNA (New York, N.Y.), Vol. 20, Issue 7, pp. 1014-22, (2014) (PubMed).

    Jakobsen, Sørensen, Brøndum, Daugaard, Thomsen, Nielsen: "Direct RNA sequencing mediated identification of mRNA localized in protrusions of human MDA-MB-231 metastatic breast cancer cells." in: Journal of molecular signaling, Vol. 8, Issue 1, pp. 9, (2013) (PubMed).

    Balamurugan, Sharan, Klarmann, Zhang, Coppola, Summers, Roger, Morrison, Keller, Sterneck: "FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4." in: Nature communications, Vol. 4, pp. 1662, (2013) (PubMed).

    Hawkins, Oliaro, Kallies, Belz, Filby, Hogan, Haynes, Ramsbottom, Van Ham, Kinwell, Seddon, Davies, Tarlinton, Lew, Humbert, Russell: "Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity." in: Nature communications, Vol. 4, pp. 1801, (2013) (PubMed).

    Grewe, Hoffmann, Ohs, Blissenbach, Brandt, Tippler, Grunwald, Uberla: "Cytoplasmic utilization of human immunodeficiency virus type 1 genomic RNA is not dependent on a nuclear interaction with gag." in: Journal of virology, Vol. 86, Issue 6, pp. 2990-3002, (2012) (PubMed).

    Sarkar, Sharan, Wang, Pawar, Cantwell, Johnson, Morrison, Wang, Sterneck: "Identification of a Src tyrosine kinase/SIAH2 E3 ubiquitin ligase pathway that regulates C/EBPδ expression and contributes to transformation of breast tumor cells." in: Molecular and cellular biology, Vol. 32, Issue 2, pp. 320-32, (2012) (PubMed).

    Hall, Cowan: "Structural features and restricted expression of a human alpha-tubulin gene." in: Nucleic acids research, Vol. 13, Issue 1, pp. 207-23, (1985) (PubMed).

  • Target
    alpha Tubulin (TUBA1)
    Andere Bezeichnung
    alpha-Tubulin (TUBA1 Produkte)
    Synonyme
    Tuba1, K-ALPHA-1, Tuba-1, cb944, fb22g06, tuba1, wu:fb22g06, Calpha1, tubulin, alpha 1A, tubulin alpha 1b, tubulin, alpha 1b, tubulin, alpha 1B, Tuba1a, TUBA1B, tuba1b, Tuba1b
    Hintergrund
    Tubulin Loading Control Antibody recognizes microtubules which are involved in a wide variety of cellular activities ranging from mitosis and transport events to cell movement and the maintenance of cell shape. Tubulin itself is a globular protein consisting of two polypeptides (alpha and beta tubulin). Alpha and beta tubulin dimers are assembled to 13 protofilaments that form a microtubule of 22-nm diameter. Tyrosine ligase adds a C-terminal tyrosine to monomeric alpha tubulin. Assembled microtubules can again be detyrosinated by a cytoskeleton-associated carboxypeptidase. Detyrosinated alpha tubulin is referred to as Glu-tubulin. Another post-translational modification of detyrosinated alpha tubulin is C-terminal polyglutamylation, which is characteristic of microtubules in neuronal cells and the mitotic spindle. This antibody makes an excellent loading control.
    Synonyms: Tubulin alpha-1B chain, Tubulin alpha-ubiquitous chain, Alpha-tubulin ubiquitous Tubulin K-alpha-1, TUBA1B, tubulin loading control
    Gen-ID
    17986283
    UniProt
    P68363
    Pathways
    Microtubule Dynamics
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