ING5 Antikörper (Inhibitor of Growth Family, Member 5) AA 127-140

Produktnummer ABIN129552

Produktdetails anti-ING5 Antikörper

Target: ING5

Bindungsspezifität: AA 127-140

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser ING5 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktmerkmale: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity purified antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding aa 127-140 of Human p28 ING5protein (Inhibitor of growth family, member 5). This sequence shows homology to and 2 for ING5.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This affinity purified antibody has been tested for use in ELISA and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 28 kDa or 26 kDa in size corresponding to variants of ING5 by western blotting in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.52 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-ING5 Antikörper (ABIN129552)

Iizuka, Sarmento, Sekiya, Scrable, Allis, Smith: "Hbo1 Links p53-dependent stress signaling to DNA replication licensing." in: Molecular and cellular biology, Vol. 28, Issue 1, pp. 140-53, (2007) (PubMed).

Details zu ING5

Target: ING5

Andere Bezeichnung: p28 ING5 (ING5 Produkte)

Synonyme: p28ING5, 1700001C14Rik, 1700027H23Rik, 1810018M11Rik, AI225768, p28ing5, MGC76007, ING5, MGC133862, ING1, p33, si:busm1-40g1.1, si:dz40g1.1, wu:fc94a02, zgc:100910, ing5, inhibitor of growth family member 5, inhibitor of growth family, member 5, inhibitor of growth family member 5 L homeolog, inhibitor of growth family, member 5b, inhibitor of growth family, member 5a, ING5, Ing5, ing5, ing5.L, ing5b, ing5a

Hintergrund: P28 ING5 is a tumor suppressor protein similar to ING1 that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway.  Multiple alternatively spliced transcript variants have been observed.  The accession number listed below is for variant (1) encodes the longest isoform.
Synonyms: ING5 antibody, Inhibitor of growth family member 5 antibody

Gen-ID: 84289, 18644730

UniProt: Q8WYH8

Pathways: Chromatin Binding