Concentration Definition: by UV absorbance at 280 nm
Immunogen
This affinity purified antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding aa 127-140 of Human p28 ING5protein (Inhibitor of growth family, member 5). This sequence shows homology to and 2 for ING5.
ING5
Reaktivität: Human
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
This affinity purified antibody has been tested for use in ELISA and by western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 28 kDa or 26 kDa in size corresponding to variants of ING5 by western blotting in the appropriate cell lysate or extract.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
1.52 mg/mL
Buffer
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Iizuka, Sarmento, Sekiya, Scrable, Allis, Smith: "Hbo1 Links p53-dependent stress signaling to DNA replication licensing." in: Molecular and cellular biology, Vol. 28, Issue 1, pp. 140-53, (2007) (PubMed).
p28ING5, 1700001C14Rik, 1700027H23Rik, 1810018M11Rik, AI225768, p28ing5, MGC76007, ING5, MGC133862, ING1, p33, si:busm1-40g1.1, si:dz40g1.1, wu:fc94a02, zgc:100910, ing5, inhibitor of growth family member 5, inhibitor of growth family, member 5, inhibitor of growth family member 5 L homeolog, inhibitor of growth family, member 5b, inhibitor of growth family, member 5a, ING5, Ing5, ing5, ing5.L, ing5b, ing5a
Hintergrund
P28 ING5 is a tumor suppressor protein similar to ING1 that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed. The accession number listed below is for variant (1) encodes the longest isoform. Synonyms: ING5 antibody, Inhibitor of growth family member 5 antibody