ING3 Antikörper (Inhibitor of Growth Family, Member 3) Isoform 1

Produktnummer ABIN129551

Produktdetails anti-ING3 Antikörper

Target: ING3

Bindungsspezifität: AA 294-304, Isoform 1

Reaktivität: Human

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser ING3 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktmerkmale: Concentration Definition: by UV absorbance at 280 nm

Immunogen: This affinity purified antibody was prepared from whole Goat serum produced by repeated immunizations with a synthetic peptide corresponding aa 294-304 of Human ING3 protein (Inhibitor of growth family, member 3). This sequence only shows homology to for ING3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: This affinity purified antibody has been tested for use in ELISA against the immunizing peptide. Specific conditions for western blotting reactivity should be optimized by the end user.  Expect a band at approximately 47 kDa in size corresponding to ING3 isoform 1 by western blotting in the appropriate cell lysate or extract.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.10 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu ING3

Target: ING3

Andere Bezeichnung: p47 ING3 (ING3 Produkte)

Synonyme: ING3, Eaf4, ING2, MEAF4, p47ING3, 1300013A07Rik, P47ING3, zgc:56327, inhibitor of growth family member 3, inhibitor of growth family, member 3, inhibitor of growth protein 3, inhibitor of growth family member 3 L homeolog, ING3, Ing3, CpipJ_CPIJ009396, ing3, ing3.L

Hintergrund: P47 ING3 is a tumor suppressor protein similar to ING1 that  can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Over-expression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Multiple alternatively spliced transcript variants have been observed.  The accession number listed below is for variant (1) that encodes the longest isoform.
Synonyms: Inhibitor of growth family member 3 antibody, Inhibitor of growth protein 3 antibody

Gen-ID: 54556, 38201655

UniProt: Q9NXR8