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MTBP Antikörper (AA 667-812)

Dieses Anti-MTBP-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von MTBP in WB und ELISA. Geeignet für Human.
Rockland
Produktnummer ABIN129549
Hersteller Produkt- Nr.: 500-301-875

Kurzübersicht für MTBP Antikörper (AA 667-812) (ABIN129549)

Target

Alle MTBP Antikörper anzeigen
MTBP (MDM2 Binding Protein (MTBP))

Reaktivität

  • 43
  • 18
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 42
  • 1
Maus

Klonalität

  • 42
  • 1
Monoklonal

Konjugat

  • 19
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MTBP Antikörper ist unkonjugiert

Applikation

  • 32
  • 13
  • 13
  • 13
  • 7
  • 4
  • 4
  • 3
  • 3
  • 2
  • 2
Western Blotting (WB), ELISA

Klon

PHL-1
  • Bindungsspezifität

    • 15
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 667-812

    Hersteller Produkt- Nr.

    500-301-875

    Hersteller

    Rockland

    Verwendungszweck

    MTBP Antibody

    Kreuzreaktivität (Details)

    This antibody is directed against human MTBP protein.

    Produktmerkmale

    Synonyms: mouse anti-MTBP antibody, mouse anti-mouse double minute 2 antibody, MDM 2 BP antibody, MDM2 (mouse double minute 2) binding protein 104kD antibody, MDM2 (mouse double minute 2) binding protein antibody, MDM2 Binding Protein antibody, MDM2 BP antibody

    Aufreinigung

    The product was produced from clarified mouse ascetic fluid.

    Sterilität

    Sterile filtered

    Immunogen

    Immunogen: This monoclonal antibody was produced by repeated immunizations with a recombinant amino-terminal HIS6X-tagged polypeptide corresponding to amino acid residues 667-812 of human MTBP protein.

    Immunogen Type: Conjugated Peptide

    Isotyp

    IgG1 kappa
  • Applikationshinweise

    Application Note: This antibody has been tested for use in ELISA and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band ~ 110 kDa in size corresponding to MTBP by western blotting in the appropriate cell lysate or extract.

    Western Blot Dilution: 1:200 - 1:2,000

    ELISA Dilution: 1:2,000 - 1:20,000

    Other: User Optimized

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative: 0.01 % (w/v) Sodium Azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

    Haltbarkeit

    12 months
  • Target

    MTBP (MDM2 Binding Protein (MTBP))

    Andere Bezeichnung

    MTBP

    Hintergrund

    Background: The MDM2 onco-protein is over expressed in human cancer cells and it promotes tumorigenesis by directly blocking the function of the p53 tumor suppressor.  Studies also indicate that MDM2 regulates cell proliferation via p53 independent mechanisms.   MTBP (Mdm2 [Two] Binding Protein) was identified by a yeast two-hybrid screen as an MDM2 binding protein (1).  MTBP has been reported to modulate cell cycle progression by a p53 independent mechanism and suppress MDM2-mediated p53 degradation when ectopically expressed in cells (1,2).   The human MTBP gene localizes to 8q24 (3) and MTBP RNA is expressed in a wide range of tissues, with highest being in the thymus, testes and ovaries (1).

    Gen-ID

    27085

    NCBI Accession

    NP_071328

    UniProt

    Q96DY7
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