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SUMO3 Antikörper (Small Ubiquitin Related Modifier 3) Primary Antibody

SUMO3 Reaktivität: Human IP, IHC, ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN129521
$744.00
Zzgl. Versandkosten $45.00
500 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 1 bis 2 Werktagen
  • Target Alle SUMO3 Antikörper anzeigen
    SUMO3
    Reaktivität
    • 55
    • 18
    • 15
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 34
    • 20
    • 2
    Kaninchen
    Klonalität
    • 40
    • 17
    Polyklonal
    Konjugat
    • 33
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SUMO3 Antikörper ist unkonjugiert
    Applikation
    • 45
    • 30
    • 15
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Produktmerkmale
    Concentration Definition: by UV absorbance at 280 nm
    Immunogen
    This purified antibody was prepared from rabbit serum after repeated immunizations with recombinant human SUMO-3 protein.
    Immunogentype:Recombinant
    Isotyp
    IgG
  • Applikationshinweise
    This purified polyclonal antibody reacts with human SUMO-3 by western blot and ELISA. Although not tested, this antibody is likely functional in immunohistochemistry and immunoprecipitation.   This antibody using the specified conditions may recognize other prominent intrinsic bands (UBLs or conjugates).  Other intrinsic bands are readily detectable at lower dilutions.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 11.6 kDa in size corresponding to human SUMO-3 by western blotting in the appropriate cell lysate or extract.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Restore with deionized water (or equivalent)
    Konzentration
    5.0 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
  • Target
    SUMO3
    Andere Bezeichnung
    SUMO-3 (SUMO3 Produkte)
    Synonyme
    SMT3A, SMT3H1, SUMO-3, Smt3B, 2810014B19Rik, AA409334, AW121497, AW536077, D10Ertd345e, Smt3h1, smt3a, smt3h1, fa94a11, im:7141764, sumo2, sumo3, sumo3l, wu:fa94a11, wu:fb55d09, zgc:65847, zgc:85643, SUMO3, ATSUMO3, MCO15.12, MCO15_12, SMALL UBIQUITIN-LIKE MODIFIER 3, SUM3, SUMO 3, small ubiquitin-like modifier 3, GMP1, PIC1, SENTRIN, SMT3, SMT3H3, SMTP3, SUMO-1, Smt3C, Ubl1, small ubiquitin-like modifier 3, small ubiquitin-like modifier 3 L homeolog, small ubiquitin-like modifier 3a, small ubiquitin-related modifier 2 pseudogene, SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae), small ubiquitin-like modifier 2, small ubiquitin-like modifier 1, SUMO3, Sumo3, sumo3.L, sumo3a, LOC490297, sumo3, sumo2, Sumo1
    Hintergrund
    Covalent modification of cellular proteins by the ubiquitin-like modifier SUMO (small ubiquitin-like modifier) regulates various cellular processes, such as nuclear transport, signal transduction, stress responses and cell cycle progression.  But, in contrast to ubiquination, sumoylation does not tag proteins for degradation by the 26S proteasome, but rather seems to enhance stability or modulate their subcellular compartmentalization.  Ubiquitin-like proteins fall into two classes: the first class, ubiquitin-like modifiers (UBLs) function as modifiers in a manner analogous to that of ubiquitin.  Examples of UBLs are SUMO, Rub1 (also called Nedd8), Apg8 and Apg12.  Proteins of the second class include parkin, RAD23 and DSK2, are designated ubiquitin-domain proteins (UDPs).  These proteins contain domains that are related to ubiquitin but are otherwise unrelated to each other.  In contrast to UBLs, UDPs are not conjugated to other proteins.  Once covalently attached to cellular targets, SUMO regulates protein:protein and protein:DNA interactions, as well as localization and stability of the target protein.  Sumoylation occurs in most eukaryotic systems, and SUMO is highly conserved from yeast to human.   Where invertebrates have only a single SUMO gene termed SMT3, three members of the SUMO family have been identified in vertebrates: SUMO-1 and the close homologues SUMO-2 and SUMO-3.  SUMO has been called SMT3 (yeast), sentrin, PIC1, GMP1 and UBL1.  SUMO has been shown to bind and regulate mammalian SP-RINGs (such as Mdm2, PIAS and PML), RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, Fas, Daxx, TNFRI, Topo-I, Topo-II, WRN, Sp100, IkB-a, Androgen receptor (AR), GLUT1/4, Drosophila Ttk69, Dorsal, CaMK, yeast Septins, and viral CMV-IE1/2, EBV-BZLF1, HPV/BPV-E1. These bindings implicate SUMO in the stabilization of the target proteins and/or their localization to subcellular complexes.  SUMO has an apparent molecular weight of ~12kDa and human SUMO-1 (a 101 amino acid polypeptide) shares 50% sequence identity with SUMO-2 and SUMO-3 and with yeast SMT3.  SUMO and ubiquitin only show about 18% homology, but both possess a common three-dimensional structure characterized by a tightly packed globular fold with b-sheets wrapped around an a-helix.
    Synonyms: Small ubiquitin related modifier 3 antibody, SMT3 homolog 1 antibody, SMT3A antibody, SMT3H1 antibody, SUMO3 antibody, Ubiquitin like protein SMT3A antibody
    Gen-ID
    6612, 48928058
    UniProt
    P55854
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