MAPK8IP1 Antikörper

Produktnummer ABIN127294

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch MAPK8IP1 in WB. Es zeigt Reaktivität gegenüber Proben von Ratte und Maus.

Kurzübersicht für MAPK8IP1 Antikörper (ABIN127294)

Target: MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1))

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAPK8IP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MAPK8IP1 Antikörper

Spezifität: The antibody recognizes 78 kDa JIP1.

Aufreinigung: Protein A purified

Immunogen: Synthetic peptide from mouse JIP1.

Anwendungsinformationen

Applikationshinweise: Western Blot: 0.5-4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 2 mg/mL

Buffer: PBS containing 0.5 % BSA, 30 % glycerol, and 0.01 % thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.

Details zu MAPK8IP1

Target: MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1))

Andere Bezeichnung: MAPK8IP1 / JIP1

Hintergrund: JIP1 (JNK-interacting protein-1) is a cytoplasmic protein that possesses an N-terminal JNKbinding domain and a C-terminal SRC homology 3 (SH3) domain. JIP1 selectively bind to JNK, but not to the ERK or p38 MAP kinases. In addition to JNK, JIP1 binds to specific proteins of JNK pathways, including MKK7, MLK3, and DLK, all at separate binding sites. JIP1 has been identified in brain and kidney tissues, whereas JIP2a, JIP2b, and JIP3 are specifically expressed in the brain. Overexpression of JIP1 causes cytoplamic retention of JNK, thereby preventing its nuclear accumulation and the subsequent activation of the JNK pathways, indicating that JIP1 acts as a cytoplasmic anchor for JNK.Synonyms: C-jun-amino-terminal kinase-interacting protein 1, IB1, Islet-brain 1, JIP-1, JNK MAP kinase scaffold protein 1, JNK-interacting protein 1, Mitogen-activated protein kinase 8-interacting protein 1, PRKM8IP

Gen-ID: 9479

NCBI Accession: NP_005447

UniProt: Q9UQF2