HDAC7 Antikörper

Produktnummer ABIN127244

Der Kaninchen Polyklonal anti-HDAC7 Antikörper wird verwendet zum Nachweis von HDAC7 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, IHC (p) und IP.

Kurzübersicht für HDAC7 Antikörper (ABIN127244)

Target: HDAC7 (Histone Deacetylase 7 (HDAC7))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HDAC7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Produktdetails anti-HDAC7 Antikörper

Spezifität: The antibody detects ~105 kDa HDAC7.

Aufreinigung: Affinity Purified

Immunogen: Synthetic peptide surrounding amino acid 921 of murine HDAC7

Anwendungsinformationen

Applikationshinweise: Western blotting (0.5-4 μg/mL). Mouse small intestine tissue lysate can be use as apositive control. Based on researchers feedback, this antibody can also be used inimmunoprecipitation (20-40 μg/mL) and immunohistochemistry (20-40 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.2 mg/mL

Buffer: PBS, pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: Store (in aliquots) at -20 °C to -70 °C.

Details zu HDAC7

Target: HDAC7 (Histone Deacetylase 7 (HDAC7))

Andere Bezeichnung: HDAC7

Hintergrund: Human HDAC7 is composed of 912 amino acid residues. Although HDAC7 is localized mostly to the cell nucleus, it is also found in the cytoplasm, suggesting nucleo-cytoplasmic shuttling. The histone deacetylase activity of HDAC7 maps to a carboxy-terminal domain and is dependent on interaction with class I HDACs in the nucleus. HDAC7 catalyzes removal of acetyl-groups from acetyl-lysines of histones and promotes compaction of chromatin in these regions, leading to the inhibition of gene transcription.Synonyms: HD7, HD7a, HDAC7A, Histone deacetylase 7

Gen-ID: 51564

NCBI Accession: NP_001091886

UniProt: Q8WUI4

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development