HRK Antikörper

Produktnummer ABIN127035

Produktdetails anti-HRK Antikörper

Target: HRK (Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HRK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: The antibody detects Hrk fused with green fluorescent protein in crude extracts of E. coli transfected with Hrk-GFP.

Aufreinigung: Affinity purified

Immunogen: Synthetic peptide corresponding to residues surrounding amino acids 50 of human HRK.

Anwendungsinformationen

Applikationshinweise: Western Blot: 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: PBS, pH 7.2, containing 50 % glycerol, 1 % BSA, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.

Details zu HRK

Target: HRK (Harakiri, BCL2 Interacting Protein (Contains Only BH3 Domain) (HRK))

Andere Bezeichnung: Harakiri / HRK (HRK Produkte)

Synonyme: DP5 antikoerper, HARAKIRI antikoerper, AI838259 antikoerper, Bid3 antikoerper, harakiri antikoerper, Dp5 antikoerper, harakiri, BCL2 interacting protein antikoerper, harakiri, BCL2 interacting protein (contains only BH3 domain) antikoerper, HRK antikoerper, Hrk antikoerper

Hintergrund: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3) group of the Bcl-2 family of proteins, was identified as a novel protein induced during programmed neuronal death. It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 motif of Bik. Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain. It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS. Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL. Despite its predicted molecular weight, Hrk often migrates at 12-15 kDa.Synonyms: Activator of apoptosis harakiri, BH3-interacting domain-containing protein 3, BID3, Neuronal death protein DP5

Gen-ID: 8739

NCBI Accession: NP_003797

UniProt: O00198