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SIT1 Antikörper (Signaling threshold Regulating Transmembrane Adaptor 1) (PE) Primary Antibody

SIT1 Reaktivität: Human FACS, IP, WB Wirt: Maus Monoclonal SIT-01 PE
Pubmed (2 references)
Produktnummer ABIN125717
$624.50
Zzgl. Versandkosten $45.00
0.1 mg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 5 bis 7 Werktagen
  • Target Alle SIT1 Antikörper anzeigen
    SIT1
    Reaktivität
    • 28
    • 2
    Human
    Wirt
    • 19
    • 7
    • 4
    Maus
    Klonalität
    • 26
    • 4
    Monoklonal
    Konjugat
    • 11
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    Dieser SIT1 Antikörper ist konjugiert mit PE
    Applikation
    • 22
    • 22
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Western Blotting (WB)
    Spezifität
    The antibody SIT-01 reacts with SHP2-interacting transmembrane adaptor protein (SIT) expressed exclusively in lymphoid organs. It weakly crossreacts with mouse SIT.
    Kreuzreaktivität (Details)
    Human
    Immunogen
    Bacterially produced recombinant intracellular fragment of human SIT.
    Klon
    SIT-01
    Isotyp
    IgG1
  • Applikationshinweise
    The reagent is designed for Flow Cytometry analysis (see application note on www.exbio.cz).Suggested working dilution is 1:50. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
    Kommentare

    The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.1 mg/mL
    Buffer
    The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide.
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Avoid prolonged exposure to light.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
  • Tedoldi, Paterson, Hansmann, Natkunam, Rüdiger, Angelisova, Du, Roberton, Roncador, Sanchez, Pozzobon, Masir, Barry, Pileri, Mason, Marafioti, Horejsí: "Transmembrane adaptor molecules: a new category of lymphoid-cell markers." in: Blood, Vol. 107, Issue 1, pp. 213-21, (2005) (PubMed).

    Horejsí, Zhang, Schraven: "Transmembrane adaptor proteins: organizers of immunoreceptor signalling." in: Nature reviews. Immunology, Vol. 4, Issue 8, pp. 603-16, (2004) (PubMed).

  • Target
    SIT1
    Andere Bezeichnung
    SIT (SIT1 Produkte)
    Synonyme
    SIT1, RP11-331F9.5, SIT, SIT-R, Sit, signaling threshold regulating transmembrane adaptor 1, suppression inducing transmembrane adaptor 1, SIT1, Sit1
    Hintergrund
    SIT (SHP2-interacting transmembrane adaptor protein) is expressed exclusively in lymphoid organs and acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.
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