TRIM Antikörper (Intracellular) (PE)

Produktnummer ABIN125716

Dieses Maus Monoklonal-Antikörper erkennt spezifisch TRIM in ICFC. Er zeigt eine Reaktivität gegenüber Human und wurde in 1 Publikation erwähnt.

Kurzübersicht für TRIM Antikörper (Intracellular) (PE) (ABIN125716)

Target: TRIM (TRAT1) (T Cell Receptor Associated Transmembrane Adaptor 1 (TRAT1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TRIM Antikörper ist konjugiert mit PE

Applikation: Intracellular Flow Cytometry (ICFC)

Klon: TRIM-04

Produktdetails anti-TRIM Antikörper (PE)

Bindungsspezifität: AA 29-186, Intracellular

Verwendungszweck: Anti-TRIM PE

Spezifität: The antibody TRIM-04 recognizes an intracellular epitope of T cell receptor-interacting molecule (TRIM), a 30 kDa adaptor protein expressed by T cells.

Keine Kreuzreaktivität: Maus

Kreuzreaktivität (Details): Human

Aufreinigung: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: Recombinant intracellular domain (aa 29-186) of human TRIM.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 1-4 μg/mL. Intracellular staining.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.
Avoid prolonged exposure to light.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Referenzen für anti-TRIM Antikörper (PE) (ABIN125716)

Kirchgessner, Dietrich, Scherer, Isomäki, Korinek, Hilgert, Bruyns, Leo, Cope, Schraven: "The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain." in: The Journal of experimental medicine, Vol. 193, Issue 11, pp. 1269-84, (2001) (PubMed).

Details zu TRIM

Target: TRIM (TRAT1) (T Cell Receptor Associated Transmembrane Adaptor 1 (TRAT1))

Andere Bezeichnung: TRIM

Hintergrund: T cell receptor associated transmembrane adaptor 1,TRIM (T cell receptor-interacting molecule), also known as TRAT1 (T cell receptor associated transmembrane adaptor 1) is a 30 kDa protein expressed by T cells as a cystein-linked homodimer. It associates with TCR-CD3-zeta-chain complex and becomes phosphorylated by Src-family kinases. TRIM is potentially involved in negative regulation of TCR-mediated signaling, but its role remains unclear.,TRAT, TCRIM

Gen-ID: 50852

UniProt: Q6PIZ9

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung