Metabotropic Glutamate Receptor 4 Antikörper (C-Term)

Produktnummer ABIN122590

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Metabotropic Glutamate Receptor 4 in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Maus.

Kurzübersicht für Metabotropic Glutamate Receptor 4 Antikörper (C-Term) (ABIN122590)

Target: Metabotropic Glutamate Receptor 4 (GRM4) (Glutamate Receptor, Metabotropic 4 (GRM4))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Metabotropic Glutamate Receptor 4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-Metabotropic Glutamate Receptor 4 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody reacts with mGluR4 / GRM4 at C-term.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat (see 'Immunogen Remarks')Species reactivity (tested):Human

Aufreinigung: Peptide immunogen affinity column

Immunogen: Synthetic peptide - KLH conjugated

Anwendungsinformationen

Applikationshinweise: Western Blot. Immunohistochemistry on paraffin embedded sections. Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C forlonger. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu Metabotropic Glutamate Receptor 4

Target: Metabotropic Glutamate Receptor 4 (GRM4) (Glutamate Receptor, Metabotropic 4 (GRM4))

Andere Bezeichnung: mGluR4 / GRM4

Hintergrund: The Metabotropic Glutamate Receptor mGluR4/GRM4 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group III includes GRM4, GRM6, GRM7, and GRM8 receptors that are linked to the inhibition of the cyclic AMP signaling cascade. Two protein isoforms have been reported in rat (mGluR4a 912 aa, mGluRb 983 aa), which differ at the C-terminus. GRM4 has been reported in various regions of the brain, eye, and spinal cord. ESTs have been isolated from brain, embryo, melanocyte/uterus/fetal heart, nerve, and testis libraries. GLUR4 refers to Ionotropic Glutamate Receptor 4, not to Metabotropic Glutamate Receptor 4 (mGLUR4).Synonyms: GPRC1D, MGLUR4, Metabotropic glutamate receptor 4

Gen-ID: 2914

UniProt: Q14833