CysLTR1 Antikörper (C-Term)

Produktnummer ABIN122044

Produktdetails anti-CysLTR1 Antikörper

Target: CysLTR1 (CYSLTR1) (Cysteinyl Leukotriene Receptor 1 (CYSLTR1))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CysLTR1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: Reacts with Cysteinyl Leukotriene Receptor 1 (family: GPCR, subfamily: Chemoattractant).

Kreuzreaktivität (Details): Species reactivity (expected):MouseSpecies reactivity (tested):Human

Produktmerkmale: Synonyms: Cysteinyl leukotriene receptor 1, CysLTR1, LTD4 receptor, HG55, HMTMF81, Cysteinylleukotriene D4 receptor, G-protein coupled receptor HG55

Aufreinigung: Peptide immunogen affinity column

Immunogen: Synthetic peptide - KLH conjugatedEpitope: C-terminal domain of humanGenename: CYSLTR1Remarks: The immunizing peptide shows 90 % identity (100 % similarity) with mouse and85 % identity (100 % similarity) with rat.

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry with formalin fixed paraffin embedded tissues: 9-22 μg/mLAntigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove fromheat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween(TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C forlonger. Avoid repeated freezing and thawing.
Shelf life: one year from despatch

Haltbarkeit: 12 months

Details zu CysLTR1

Target: CysLTR1 (CYSLTR1) (Cysteinyl Leukotriene Receptor 1 (CYSLTR1))

Andere Bezeichnung: CYSLTR1 (CYSLTR1 Produkte)

Synonyme: zgc:112062 antikoerper, CYSLTR1 antikoerper, CYSLT1 antikoerper, CYSLT1R antikoerper, CYSLTR antikoerper, HMTMF81 antikoerper, BB147369 antikoerper, CysLT1R antikoerper, Cyslt1 antikoerper, cysLT1R antikoerper, cysteinyl leukotriene receptor 1 antikoerper, cysltr1 antikoerper, CYSLTR1 antikoerper, Cysltr1 antikoerper, LOC100338776 antikoerper

Hintergrund: Cysteinyl leukotriene receptor 1, a Chemoattractant Receptor, is detected in spleen, peripheral blood leukocytes, and lung smooth muscle (Lynch et al., 1999). It binds cysteinyl leukotrienes, which are neutrophil chemoattractants with potent proinflammatory action. Leukotrienes mediate many features of bronchial asthma such as edema, bronchial constriction, and hyperreactivity (Bisgaard et al., 2000). Selective CysLT1 antagonists are used to treat asthma. Ligand: The cysteinyl leukotrienes, leukotriene C4 (LTC4), leukotriene D4 (LTD4), and leukotriene E4 (LTE4) activate at least two receptors, CysLT1 and CysLT2, to mediate human bronchial asthma. LTC(4), LTD(4), and LTE(4) are a class of peptide-conjugated lipids formed from arachidonic acid and that are released during activation of mast cells.Synonyms: CysLTR1, Cysteinyl leukotriene D4 receptor, Cysteinyl leukotriene receptor 1, G-protein coupled receptor HG55, HG55, HMTMF81, LTD4 receptor

Gen-ID: 10800

UniProt: Q9Y271