CysLTR1 Antikörper (3rd Extracellular Domain)

Produktnummer ABIN122043

Dieses Anti-CysLTR1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CysLTR1 in IHC (p). Geeignet für Human, Maus und Ratte.

Kurzübersicht für CysLTR1 Antikörper (3rd Extracellular Domain) (ABIN122043)

Target: CysLTR1 (CYSLTR1) (Cysteinyl Leukotriene Receptor 1 (CYSLTR1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CysLTR1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CysLTR1 Antikörper

Bindungsspezifität: 3rd Extracellular Domain

Spezifität: Reacts with Cysteinyl Leukotriene Receptor 1(Family: GPCR, Subfamily: Chemoattractant).

Produktmerkmale: Synonyms: Cysteinyl leukotriene receptor 1, CysLTR1, LTD4 receptor, HG55, HMTMF81, Cysteinylleukotriene D4 receptor, G-protein coupled receptor HG55

Aufreinigung: Peptide immunogen affinity column

Immunogen: Synthetic peptide - KLH conjugatedEpitope: 3rd extracellular domain of humanGenename: CYSLTR1Remarks: The immunizing peptide shows 80 % identity (85 % similarity) with mouse and75 % identity (90 % similarity) with rat.

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry with formalin fixed paraffin embedded tissues: 6 -14g/mL. Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove fromheat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween(TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: PBS, containing 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-80 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CysLTR1

Target: CysLTR1 (CYSLTR1) (Cysteinyl Leukotriene Receptor 1 (CYSLTR1))

Andere Bezeichnung: CYSLTR1

Hintergrund: Cysteinyl leukotriene receptor 1, a Chemoattractant Receptor, is detected in spleen, peripheral blood leukocytes, and lung smooth muscle (Lynch et al., 1999). It binds cysteinyl leukotrienes, which are neutrophil chemoattractants with potent proinflammatory action. Leukotrienes mediate many features of bronchial asthma such as edema, bronchial constriction, and hyperreactivity (Bisgaard et al., 2000). Selective CysLT1 antagonists are used to treat asthma. The cysteinyl leukotrienes, leukotriene C4 (LTC4), leukotriene D4 (LTD4), and leukotriene E4 (LTE4) activate at least two receptors, CysLT1 and CysLT2, to mediate human bronchial asthma. LTC(4), LTD(4), and LTE(4) are a class of peptide-conjugated lipids formed from arachidonic acid and that are released during activation of mast cells.Synonyms: CysLTR1, Cysteinyl leukotriene D4 receptor, Cysteinyl leukotriene receptor 1, G-protein coupled receptor HG55, HG55, HMTMF81, LTD4 receptor

Gen-ID: 10800

UniProt: Q9Y271