CALCRL Antikörper (Cytoplasmic Domain)

Produktnummer ABIN122018

Der Kaninchen Polyklonal Anti-CALCRL-Antikörper wurde für IHC (p) validiert. Er ist geeignet, CALCRL in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für CALCRL Antikörper (Cytoplasmic Domain) (ABIN122018)

Target: CALCRL (Calcitonin Receptor-Like (CALCRL))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CALCRL Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CALCRL Antikörper

Bindungsspezifität: Cytoplasmic Domain

Spezifität: Reacts with Calcitonin Receptor-Like Receptor (Family: GPCR, subfamily: Adrenomedullin). BLAST analysis of the peptide immunogen showed no homology with other Human proteins, except CALCR (56 %).

Kreuzreaktivität (Details): Species reactivity (expected):Mouse (93 % identity and similarity) and Rat (100 % identity and similarity).
Species reactivity (tested):Human.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Synthetic peptide - KLH conjugated

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry with formalin fixed paraffin embedded tissues: 34 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C forlonger. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CALCRL

Target: CALCRL (Calcitonin Receptor-Like (CALCRL))

Andere Bezeichnung: CGRP Type 1 Receptor / CRLR

Hintergrund: Calcitonin receptor-like receptor (CRLR) is an Adrenomedullin Receptor that requires two additional proteins to function: a chaperone protein RAMP (receptor activity modifying protein) and the component protein RCP. The function of CRLR depends on its interaction with RAMP. When coexpressed with RAMP1, CRLR acts as a receptor for calcitonin gene-related peptide (CGRP). In contrast, when CRLR is coexpressed with either RAMP2 or RAMP3, it acts as a receptor for adrenomedullin. Activation of the receptor leads to an increase in intracellular cyclic AMP. CRLR mediates the vasorelaxation of arteries, suggesting a potential role for the receptor in reaction to injury, particularly in the treatment of pulmonary hypertension. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B-Cell/lung/testis, bone marrow, embryo, lung, and synovium libraries.Synonyms: CALCRL, CGRPR, Calcitonin gene-related peptide type 1 receptor, Calcitonin receptor-like receptor

Gen-ID: 10203

UniProt: Q16602

Pathways: cAMP Metabolic Process