CD8 Antikörper

Produktnummer ABIN120696

Dieser Anti-CD8 Antikörper ist ein Maus Monoklonal Antikörper zur Detektion von CD8 in FACS und IP. Geeignet für Human.

Kurzübersicht für CD8 Antikörper (ABIN120696)

Target: CD8

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD8 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP)

Klon: MEM-31

Produktdetails anti-CD8 Antikörper

Spezifität: The antibody recognizes a conformationally-dependent epitope of CD8 antigen.

Produktmerkmale: Synonyms: T-lymphocyte differentiation antigen T8/Leu-2, T-cell surface glycoprotein CD8 alpha chain

Aufreinigung: Protein-A affinity chromatography

Reinheit: > 95 % pure (by SDS-PAGE)

Immunogen: Crude thymus membrane fraction.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Flow Cytometry. Immunoprecipitation. Does not work in Western blot or Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 4-8 °C for one month or at -20 °C for longer. Avoid repeated freezingand thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CD8

Target: CD8

Andere Bezeichnung: CD8

Hintergrund: The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as ab heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as aa homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8b level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 a-b but not a-a dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.Synonyms: CD8 alpha chain, CD8A, MAL, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2

Gen-ID: 925

UniProt: P01732