CD8 Antikörper

Produktnummer ABIN1177374

Dieser Anti-CD8-Antikörper ist ein Maus-Monoklonal-Antikörper zum Nachweis von CD8 in FACS. Geeignet für Human.

Kurzübersicht für CD8 Antikörper (ABIN1177374)

Target: CD8

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD8 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: RPA-T8

Produktdetails anti-CD8 Antikörper

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Isotyp: IgG1 kappa

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Konservierungsmittel: Azide free

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Details zu CD8

Target: CD8

Andere Bezeichnung: CD8

Hintergrund: The RPA-T8 monoclonal antibody specifically binds to CD8 alpha (CD8alpha). CD8alpha is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. CD8alpha is expressed by the majority of thymocytes, by subpopulations of alphabeta T cells and gammadelta T cells and by some NK cells. Cell surface CD8alpha is expressed either as a disulfide-linked homodimer (CD8alphaalpha) or as a heterodimer (CD8alphabeta) when disulfide-bonded to a CD8 beta chain (CD8beta). CD8-positive alphabeta T cells coexpress both CD8alphaalpha homodimers and CD8alphabeta heterodimers whereas some gammadelta T cells and NK cells express CD8alphaalpha homodimers. CD8 plays important roles in T cell activation and selection. The extracellular IgSF domain of CD8alpha binds to a non-polymorphic determinant on HLA class I molecules (alpha3 domain) and enables CD8 to function as a co-receptor with MHC class I-restricted TCR during T cell recognition of antigen. The cytoplasmic domain of CD8alpha associates with Lck, a Src family protein tyrosine kinase that is involved in intracellular signaling. The RPA-T8 and HIT8a (Cat. No. 555337) monoclonal antibodies are not cross-blocking.
Synonyms: CD8alpha, CD8A, CD8 alpha, Leu2, MAL, T8, p32