NCR1 Antikörper

Produktnummer ABIN1177346

Der Maus Monoklonal Anti-NCR1-Antikörper wurde für FACS und Func validiert. Er ist geeignet, NCR1 in Proben von Human zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für NCR1 Antikörper (ABIN1177346)

Target: NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NCR1 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Functional Studies (Func)

Klon: 9E2-NKp46

Produktdetails anti-NCR1 Antikörper

Marke: BD Pharmingen™

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: This NA/LE™ format is useful for in vitro functional studies.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Konservierungsmittel: Azide free

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Referenzen für anti-NCR1 Antikörper (ABIN1177346)

Mandelboim, Porgador: "NKp46." in: The international journal of biochemistry & cell biology, Vol. 33, Issue 12, pp. 1147-50, (2001) (PubMed).

Sivori, Pende, Bottino, Marcenaro, Pessino, Biassoni, Moretta, Moretta et al.: "NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against ..." in: European journal of immunology, Vol. 29, Issue 5, pp. 1656-66, (1999) (PubMed).

Sivori, Vitale, Morelli, Sanseverino, Augugliaro, Bottino, Moretta, Moretta: "p46, a novel natural killer cell-specific surface molecule that mediates cell activation." in: The Journal of experimental medicine, Vol. 186, Issue 7, pp. 1129-36, (1997) (PubMed).

Details zu NCR1

Target: NCR1 (Natural Cytotoxicity Triggering Receptor 1 (NCR1))

Andere Bezeichnung: NKp46

Hintergrund: NKp46, a major cytoxicity receptor of NK cells, is a type I membrane glycoprotein (46 kDa) is expressed on resting and activated NK cells. Its extracellular region contains two C2-type, Ig-like domains. The transmembrane domain contains a positively charged amino acid (Arg) which could be involved in stabilizing the association with CD3zeta. Its intracellular region does not contain immunoreceptor tyrosine-based activating motifs (ITAM), but it is linked to intracytoplasmic transduction machinery by its association with CD3zeta and FcepsilonRIgamma adaptor proteins. NKp46 along with NKp30 and NKp44 are referred to as natural cytoxicity receptors (NCR) and play a very important role in killing virus-infected, tumor cells and MHC-class I-unprotected cells. This antibody is routinely tested by flow cytometric analysis.

Pathways: Regulation of Leukocyte Mediated Immunity