ITGA4 Antikörper

Produktnummer ABIN1177343

Der Maus Monoklonal Anti-ITGA4-Antikörper wurde für FACS validiert. Er ist geeignet, ITGA4 in Proben von Human, Rind (Kuh), Hund, Pferd, Cat, Schaf, Cynomolgus, Rhesusaffen und Pavian zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für ITGA4 Antikörper (ABIN1177343)

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Reaktivität: Human, Rind (Kuh), Hund, Pferd, Cat, Schaf, Cynomolgus, Rhesusaffen, Pavian

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ITGA4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: 9F10

Produktdetails anti-ITGA4 Antikörper

Marke: BD Pharmingen™

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Isotyp: IgG1 kappa

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Konservierungsmittel: Azide free

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Referenzen für anti-ITGA4 Antikörper (ABIN1177343)

Berlin, Berg, Briskin, Andrew, Kilshaw, Holzmann, Weissman, Hamann, Butcher: "Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1." in: Cell, Vol. 74, Issue 1, pp. 185-95, (1993) (PubMed).

Details zu ITGA4

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Andere Bezeichnung: CD49d

Hintergrund: The 9F10 monoclonal antibody specifically reacts with the integrin alpha4 chain, that is expressed as a heterodimer with either of two beta integrin subunits, beta1 (CD29) or beta7. The alpha4beta1 integrin (VLA-4) is expressed on lymphocytes, monocytes, thymocytes, NK cells, and several B- and T-cell lines, and mediates binding to VCAM-1 (CD106) and the CS-1 region of fibronectin. The alpha4beta7 integrin has a similar tissue distribution, except it is found on only a small subpopulation of thymocytes. Integrin alpha4beta7 also binds fibronectin and VCAM-1, and has been shown in the mouse to preferentially bind the mucosal vascular addressin molecule, MAdCAM-1. This antibody is useful for studies of the expression by and function of cells that express alpha4 chain-containing integrins.
Synonyms: Integrin alpha4 chain, Integrin alpha 4, ITGA4, IA4, alpha 4 subunit of VLA-4

Pathways: Integrin Complex