ITGA4 Antikörper

Produktnummer ABIN1177343

Es gibt 1 Publikation für dieses Produkt. Der Maus Monoklonal anti-ITGA4 Antikörper wird verwendet zum Nachweis von ITGA4 in Proben von Human, Rind (Kuh), Hund, Pferd, Cat, Schaf, Cynomolgus, Rhesusaffen und Pavian. Er wurde validiert für FACS.

Kurzübersicht für ITGA4 Antikörper (ABIN1177343)

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Reaktivität: Human, Rind (Kuh), Hund, Pferd, Cat, Schaf, Cynomolgus, Rhesusaffen, Pavian

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ITGA4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: 9F10

Produktdetails anti-ITGA4 Antikörper

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Isotyp: IgG1 kappa

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Konservierungsmittel: Azide free

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Referenzen für anti-ITGA4 Antikörper (ABIN1177343)

Berlin, Berg, Briskin, Andrew, Kilshaw, Holzmann, Weissman, Hamann, Butcher: "Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1." in: Cell, Vol. 74, Issue 1, pp. 185-95, (1993) (PubMed).

Details zu ITGA4

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Andere Bezeichnung: CD49d

Hintergrund: The 9F10 monoclonal antibody specifically reacts with the integrin alpha4 chain, that is expressed as a heterodimer with either of two beta integrin subunits, beta1 (CD29) or beta7. The alpha4beta1 integrin (VLA-4) is expressed on lymphocytes, monocytes, thymocytes, NK cells, and several B- and T-cell lines, and mediates binding to VCAM-1 (CD106) and the CS-1 region of fibronectin. The alpha4beta7 integrin has a similar tissue distribution, except it is found on only a small subpopulation of thymocytes. Integrin alpha4beta7 also binds fibronectin and VCAM-1, and has been shown in the mouse to preferentially bind the mucosal vascular addressin molecule, MAdCAM-1. This antibody is useful for studies of the expression by and function of cells that express alpha4 chain-containing integrins.
Synonyms: Integrin alpha4 chain, Integrin alpha 4, ITGA4, IA4, alpha 4 subunit of VLA-4

Pathways: Integrin Complex