IL-10RA Antikörper

Produktnummer ABIN1177308

Zitiert in 2+ Publikationen. Der Ratte Monoklonal anti-IL-10RA Antikörper (Klon 3F9) (ABIN1177308) detektiert spezifisch IL-10RA in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für IL-10RA Antikörper (ABIN1177308)

Target: IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))

Reaktivität: Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser IL-10RA Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: 3F9

Produktdetails anti-IL-10RA Antikörper

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Isotyp: IgG2a kappa

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Konservierungsmittel: Azide free

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Referenzen für anti-IL-10RA Antikörper (ABIN1177308)

Liu, de Waal Malefyt, Briere, Parham, Bridon, Banchereau, Moore, Xu: "The EBV IL-10 homologue is a selective agonist with impaired binding to the IL-10 receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 2, pp. 604-13, (1997) (PubMed).

Carson, Lindemann, Baiocchi, Linett, Tan, Chou, Narula, Caligiuri: "The functional characterization of interleukin-10 receptor expression on human natural killer cells." in: Blood, Vol. 85, Issue 12, pp. 3577-85, (1995) (PubMed).

Details zu IL-10RA

Target: IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))

Andere Bezeichnung: CD210

Hintergrund: Reacts with 90-110 kDa protein expressed on T cells, B cells, NK cells, and monocyte/macrophages. It belongs to the class II cytokine receptor family which includes IFNgammaR (CDw119), IFNalpha/betaR (CD118) and tissue factor (CD142). IL-10R has been found to play a role in signal transduction by activating specific STAT proteins (STAT3 and STAT1) and inducing gene transcription. Other reports indicate that IL-10 protein binding to NK cells appears to be stimulatory, in contrast to its binding to T cells and monocytes/macrophages. Clone 3F9 is specific for human IL-10R and its binding to the receptor can be blocked by recombinant human IL-10 (rhIL-10).
Synonyms: IL-10 receptor

Pathways: Growth Factor Binding